Clinical and epidemiological characteristics of tuberculosis combined with HIV infection
10.11816/cn.ni.2025-241901
- VernacularTitle:肺结核合并HIV感染临床及流行病学特征
- Author:
Fangfang SUN
1
;
Xiaoxin XIE
;
Wenyao TU
;
Yuedong LIANG
Author Information
1. 贵州医科大学临床医学院,贵州贵阳 550004;贵阳市公共卫生救治中心感染科,贵州贵阳 550004
- Publication Type:Journal Article
- Keywords:
Human immunodeficiency virus;
Tuberculosis;
Epidemiology;
Imaging findings;
Helper T lympho-cytes;
Cytokines;
Viral load
- From:
Chinese Journal of Nosocomiology
2025;35(16):2450-2454
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the epidemiological characteristics of tuberculosis complicated with human im-munodeficiency virus(HIV)infection and their relationships with T helper lymphocyte(Th)1/Th2 related fac-tors.METHODS From May 2022 to Feb.2024,118 patients with tuberculosis combined with HIV infection admit-ted to Guiyang Public Health Rescue Center were selected as the study group.The patients were divided into group A(＞1.0E3 cp/ml＜1.0E4 cp/ml)with 31 cases,group B(≥1.0E4 cp/ml＜1.0E5 cp/ml)with 36 cases,group C(≥1.0E5 cp/ml)with 51 cases according to viral load.Another 120 patients with simple pulmonary tu-berculosis were selected as control group.The characteristics of epidemic cases,imaging CT features and levels of Th1/Th2 related cytokines[including interleukin-2(IL-2),tumor necrosis factor-α(TNF-α),interferon γ(IFN-γ),IL-4,IL-6 and IL-10]were compared between the study group and the control group,and the relationship be-tween viral load and atypical CT manifestations of tuberculosis were analyzed.RESULTS There were significant differences in educational level,occupational status,intravenous drug use history and baseline CD4 values between the two groups(P＜0.05).The study group showed higher rates of CT manifestations such as multiple pulmona-ry fields and segments exudation,extrapulmonary tuberculosis,multiple cavities,intrathoracic lymph node en-largement,multiple nodules,and diffuse miliary shadow than the control group,conversely,the frequencies of single cavity,calcification and speckle shadow in the study group were lower than those in the control group(P＜0.05).Compared with the control group,the levels of IL-2,TNF-α and IFN-γ in the study group were low,while the levels of IL-4,IL-6 and IL-10 were high(P＜0.05).With the increase of viral load,the rates of atypical CT tuberculosis were also increased(P＜0.05).CONCLUSION The CT imaging findings in patients with tuberculosis combined with HIV infection are atypical and Th1/Th2 related cytokines are abnormal,and the chest CT manifes-tations are associated with high viral load.
