Clinical Characteristics of Blood Pressure Variability and Cardiac Structure and Function in Patients with Essential Hypertension Complicat-ed with Tumor
10.11969/j.issn.1673-548X.2025.02.014
- VernacularTitle:原发性高血压合并肿瘤患者血压变异性及心脏结构功能的临床特点
- Author:
Jiaxin LI
1
;
Futian SHI
;
Caie LI
Author Information
1. 730030 兰州大学第二临床医学院
- Publication Type:Journal Article
- Keywords:
Tumor;
ABPM;
Nighttime blood pressure fall rate;
Interventricular septum thickness
- From:
Journal of Medical Research
2025;54(2):82-87
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the differences in ambulatory blood pressure monitoring(ABPM)parameters and cardiac struc-ture and function indicators in patients with essential hypertension complicated with tumor,then to summarize the relationship between tumor and blood pressure and structural and function of the heart.Methods A retrospective study was conducted to select patients with essential hypertensive admitted to the Second Hospital of Lanzhou University from January 2018 to July 2024.A total of 109 patients with tumor combined with hypertension and 98 patients with hypertension were identified.General information,ABPM parameters,and echo-cardiography results of patients in the two groups were collected,to analyze the differences in ABPM parameters and cardiac structure and function between the two groups.Results Compared with the hypertension group,the tumor combined with hypertension group had a re-duced nighttime systolic blood pressure fall rate,nighttime diastolic blood pressure fall rate,daytime and 24-hour systolic and diastolic blood pressure standard deviations,and left ventricular ejection fraction(all P＜0.05),while the left ventricular end-diastolic diameter and interventricular septum thickness were increased(all P＜0.05).Pearson correlation analysis revealed that the nighttime systolic blood pressure fall rate was negatively correlated with age,nighttime systolic blood pressure,and morning systolic blood pressure(all P＜0.05).In the tumor combined with hypertension patients,the interventricular septum thickness was positively correlated with body mass index,nighttime systolic blood pressure,nighttime diastolic blood pressure,and 24-hour diastolic blood pressure(all P＜0.05).Multi-ple linear regression analysis results indicated that tumor and increasing age were independent risk factors for the reduction in nighttime systolic blood pressure fall rate.Conclusion Compared with hypertensive patients,patients with tumor combined with hypertension ex-hibit abnormal blood pressure circadian rhythm,increased left ventricular end-diastolic diameter,thickening of the interventricular sep-tum,and reduced ejection fraction.The presence of tumor and increasing age in patients with essential hypertension are the main risk fac-tors affecting the nighttime blood pressure fall rate.
