BK virus nephropathy after allogeneic hematopoietic stem cell transplantation: a case report and literature review
10.3760/cma.j.121090-20240810-00298
- VernacularTitle:异基因造血干细胞移植后BK病毒肾病1例报告及文献复习
- Author:
Wenli ZHANG
1
;
Yingling ZU
;
Zhenghua HUANG
;
Zhen LI
;
Ruirui GUI
;
Juan WANG
;
Xianjing WANG
;
Huili WANG
;
Xinxin FAN
;
Yongping SONG
;
Baijun FANG
;
Jian ZHOU
Author Information
1. 郑州大学附属肿瘤医院，河南省肿瘤医院血液科，郑州 450008
- Publication Type:Journal Article
- From:
Chinese Journal of Hematology
2025;46(3):273-275
- CountryChina
- Language:Chinese
-
Abstract:
A 20-year-old male patient with T-lymphoblastic lymphoma/leukemia received 9/10 human leukocyte antigen-compatible unrelated peripheral blood stem cell transplantation. He was transplanted with 5.91×10 8 mononuclear cells/kg and 2.88×10 6 CD34 + cells/kg, and neutrophil engraftment was obtained at +11 days and platelet engraftment at +9 days. After transplantation, he presented with repeatedly increased serum creatinine levels, BK virus (BKV) -associated hemorrhagic cystitis, and BKV viremia. BK virus nephropathy was diagnosed based on renal biopsy and metagenomic next-generation sequencing. After adjusting the immunosuppressant, intravenous immunoglobulin, and donor lymphocyte infusion treatment, the patient’s renal function deteriorated progressively, and he eventually died of multiple organ failure at +289 days.
