Role of stress granules in aging-related diseases
10.3760/cma.j.issn.0254-9026.2025.07.020
- VernacularTitle:应激颗粒在衰老相关疾病中的研究进展
- Author:
Yangziyu XIANG
1
;
Jieyuan JIN
;
Jianjun OU
Author Information
1. 中南大学湘雅医学院生命科学学院，长沙 410013
- Publication Type:Journal Article
- Keywords:
Aging;
RNA-binding proteins;
Stress granules;
RNA metabolism
- From:
Chinese Journal of Geriatrics
2025;44(7):974-980
- CountryChina
- Language:Chinese
-
Abstract:
Stress granules are highly dynamic, membrane-free organelles that form in cells under stress conditions through liquid-liquid phase separation.Their main components are RNA and proteins, and they play a role in RNA metabolism, among other functions.The formation, dispersion, and removal of stress granules are regulated by the rapamycin pathway, the eukaryotic translation initiation factor pathway, and modifications of RNA-binding proteins.While physiological stress granules are typically transient, chronic stress associated with aging can lead to homeostatic imbalance and persistence of these granules.This aberrant RNA metabolism can result in the pathological aggregation of RNA-binding proteins, cellular damage, and the formation of pathological stress granules, which may accelerate the progression of aging-related diseases such as Alzheimer's disease, amyotrophic lateral sclerosis, and tumors.In this paper, we will summarize the connection between stress granules and aging-related diseases to provide new insights for disease diagnosis and research.
