Retinal neurovascular characteristics and their correlation with depression severity in patients with coronary artery disease and depression
10.3969/j.issn.1006-5725.2025.04.008
- VernacularTitle:冠心病伴抑郁患者视网膜神经血管特征及其与抑郁严重程度的相关性
- Author:
Xue HE
1
;
Huan MA
;
Cong LI
;
Yan WANG
;
Yu KUANG
;
Lei LIU
;
Hong-hua YU
;
Xiaohong YANG
Author Information
1. 华南理工大学医学院(广东 广州 510006);南方医科大学附属广东省人民医院(广东省医学科学院)广东省眼病防治研究所(广东 广州 510080)
- Publication Type:Journal Article
- Keywords:
coronary artery disease;
depressive disorders;
optical coherence tomography angiography
- From:
The Journal of Practical Medicine
2025;41(4):515-521
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate retinal vascular and neural changes in patients with coronary artery disease with depression(CADD)and to investigate their association with depression severity.Methods A total of 40 patients with CADD,56 patients with CAD without depressive disorder(CADND),and 31 healthy controls were included in this study.The vessel density of superficial capillary plexus(SCP)and deep capillary plexus(DCP),and the thickness of the retinal nerve fiber layer(RNFL)and ganglion cell complex(GCC),were quanti-fied using optical coherence tomography angiography(OCTA)to analyze the differences between the groups and their correlation with PHQ-9 scores.Results Compared with the healthy control group,SCP and DCP were signifi-cantly decreased in both CADD and CADND groups(P<0.05).Both superior hemi in RNFL thickness and GCC thickness(including mean,superior hemi,and inferior hemi)were significantly increased in patients with CADD compared with patients with CADND(P<0.05).PHQ-9 scores were negatively correlated with the mean and infe-rior RNFL thickness(P<0.05).Conclusion Both retinal vascular neural structures were altered in patients with CADD,and the neural alterations were strongly correlated with the severity of the patient's depression symptom.
