Study the effect of rhGM-CSF combined with bifidobacterium treating on stomatitis after chemotherapy
10.3969/j.issn.1673-9701.2025.23.012
- VernacularTitle:rhGM-CSF联合双歧杆菌治疗化疗后口腔黏膜炎的疗效研究
- Author:
Qinghua LAN
1
;
Qingfang ZENG
;
Wei XIAO
;
Tao ZHAN
;
Jianming ZHONG
;
Liujin QIU
Author Information
1. 江西省赣州市肿瘤医院血液淋巴肿瘤病区,江西赣州 341000
- Publication Type:Journal Article
- Keywords:
Oral mucositis;
Bifidobacterium;
Recombinant human granulocyte-macrophage colony-stimulating factor;
Oral microecology
- From:
China Modern Doctor
2025;63(23):50-53
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of recombinant human granulocyte-macrophage colony-stimulating factor(rhGM-CSF)combined with bifidobacterium in the treatment of oral mucositis after chemotherapy.Methods A total of 60 post-chemotherapy patients with oral mucositis admitted to Ganzhou Cancer Hospital of Jiangxi Province from January 2023 to December 2024 were selected as subjects,the patients were divided into observation group(n=30)and control group(n=30)by using a randomized digital table method.The control group received rhGM-CSF mouthwash treatment,while the observation group was additionally administered bifidobacterium-lactobacillus triple live capsules orally.Clinical efficacy,symptom scores,inflammatory factor levels,oral microbiota indicators,and treatment safety were evaluated after 2 weeks of treatment.Results After treatment,the total effective rate in observation group was significantly higher than that in control group(P＜0.05).Post-treatment evaluations showed that patients in observation group exhibited lower scores for edema,congestion,and ulceration,along with reduced pain visual analog scores and decreased levels of inflammatory markers including Toll-like receptor 4,lectin-3,and interleukin-8,the difference were statistically significant(P＜0.05).After treatment,the oral microecological flora of patients in observation group,including lactic acid bacteria and bifidobacterium,were higher than that of control group,while porphyromonas gingivalis and fusetella were lower than that of control group,the difference were statistically significant(P＜0.05).Conclusion The clinical effect of rhGM-CSF combined with bifidobacterium in the treatment of oral mucositis after chemotherapy was significant,which could reduce various symptoms of patients,inhibit inflammatory factors,improve oral microecology,and have good safety.
