Advances and challenges of 18 kDa translocator protein(TSPO)-PET imaging in neurodegenerative diseases
10.13929/j.issn.1003-3289.2025.10.031
- VernacularTitle:18 kDa转位蛋白(TSPO)-PET显像用于神经退行性疾病:进展与挑战
- Author:
Shixiang ZHANG
1
;
Jin GAO
;
Yidan WEI
;
Liping FU
Author Information
1. 中日友好医院(中日友好临床医学研究所)/北京协和医学院/中国医学科学院,北京 100029
- Publication Type:Journal Article
- Keywords:
neurodegenerative diseases;
positron-emission tomography;
18 kDa translocator protein
- From:
Chinese Journal of Medical Imaging Technology
2025;41(10):1750-1754
- CountryChina
- Language:Chinese
-
Abstract:
Neurodegenerative diseases(NDD)are a heterogeneous group of disorders characterized by neuronal degeneration and functional impairment,in which neuroinflammation plays a pivotal role throughout disease onset and progression.The 18 kDa translocator protein(TSPO)serves as an important molecular biomarker of neuroinflammation,with its expression closely associated with activation of microglia and astrocytes.TSPO-PET enables noninvasive and dynamic mapping of spatiotemporal distribution of cerebral neuroinflammation,providing crucial molecular imaging evidence for early diagnosis,disease evaluation and therapeutic response assessment of NDD.The advances and challenges of TSPO-PET imaging in NDD were reviewed in this article.
