Diffusion tensor imaging analysis index along the perivascular space for assessing age-related functional changes in glymphatic system
10.13929/j.issn.1003-3289.2025.10.011
- VernacularTitle:基于沿血管周围间隙弥散张量成像分析指数评估年龄相关类淋巴系统功能变化
- Author:
Xiaofeng CHEN
1
;
Hao ZHANG
;
Yulin LIN
;
Jiada YANG
;
Xiaoli XIONG
;
Jialin WU
;
Weixiong FAN
;
Zhiqi YANG
Author Information
1. 梅州市人民医院放射科,广东梅州 514031;广东省临床分子诊断与抗体药物工程技术研究中心,广东梅州 514031
- Publication Type:Journal Article
- Keywords:
brain;
homeostasis;
age factors;
diffusion tensor imaging
- From:
Chinese Journal of Medical Imaging Technology
2025;41(10):1659-1662
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of diffusion tensor imaging analysis index along the perivascular space(DTI-ALPS)for assessing age-related functional changes in glymphatic system(GS).Methods Totally 27 healthy subjects from Meizhou People's Hospital and 100 healthy subjects from neuroimaging informatics tools and resources collaborator database who underwent T1-weighted magnetization-prepared rapid gradient echo(T1-MPRAGE)and DTI scanning were retrospectively enrolled and divided into youth group(n=38),middle-aged group(n=57)and elderly group(n=32).Automated DTI-ALPS index analysis procedure was used to minimize manual errors and derive DTI-ALPS index.The general data,neuropsychological assessment results and DTI-ALPS indices were compared among groups.Spearman correlation analysis was performed to observe the relationships of DTI-ALPS index and age,gender,as well as neuropsychological scores.Results The average age in youth group,middle-aged group and elderly group was(28.5±5.8),(53.7±6.8)and(73.8±2.3)years,respectively.No significant difference of DTI-ALPS index was found between middle-aged group and elderly group(P＞0.05),which were both lower than that in youth group(both P＜0.05).DTI-ALPS index was weakly negatively correlated with age(rs=-0.340,P＜0.001),but not significantly correlated with gender nor neuropsychological assessment results(both P＞0.05).Conclusion DTI-ALPS index was negatively correlated with age in healthy individuals,hence having potential utility for assessing age-related functional changes in GS.
