Research progress on comprehensive treatment for advanced intrahepatic cholangiocarcinoma
10.3781/j.issn.1000-7431.2025.2405-0282
- VernacularTitle:晚期肝内胆管癌综合治疗研究进展
- Author:
Wenqi TAO
1
;
Yingbin LIU
1
Author Information
1. 上海交通大学医学院附属仁济医院胆胰外科,上海 200127;上海市肿瘤研究所,上海 200127;上海市肿瘤系统调控与转化重点实验室,上海 200127
- Publication Type:Journal Article
- Keywords:
Intrahepatic cholangiocarcinoma;
Chemotherapy;
Targeted therapy;
Immunotherapy;
Local treatment
- From:
Tumor
2025;45(3):307-316
- CountryChina
- Language:Chinese
-
Abstract:
Intrahepatic cholangiocarcinoma(ICC)is a malignant tumor originating from the epithelial cells of the intrahepatic bile ducts,with adenocarcinoma being its predominant pathological type.Due to its insidious onset and the difficulty of early diagnosis,ICC has a high mortality rate.Currently,complete resection of the tumor through surgery remains the only potential curative treatment for ICC,but only a small proportion of patients are eligible for surgery.In this context,a multidisciplinary comprehensive treatment model,centered around surgery and combined with systemic chemotherapy,targeted therapy,immunotherapy,supplemented by local interventional therapies and radiotherapy,has emerged as an effective strategy for improving the prognosis of ICC patients.This paper systematically reviews the latest research advances in chemotherapy,targeted therapy,immunotherapy,and local treatment for ICC,and summarizes the current clinical treatment strategies,aiming to provide a robust reference for the precise treatment of patients with advanced ICC.
