Doxorubicin hydrochloride liposomes combined with iodized oil in hepatic arterial embolization of rabbit VX2 liver tumor:Pharmacokinetics and pharmacodynamics study
10.13929/j.issn.1672-8475.2025.02.010
- VernacularTitle:盐酸多柔比星脂质体联合碘化油肝动脉栓塞治疗兔VX2肝癌:药代动力学及药效学研究
- Author:
Yihao ZHAO
1
;
Haochen WANG
1
;
Long JIN
1
Author Information
1. 首都医科大学附属北京友谊医院放射介入科,北京 100050
- Publication Type:Journal Article
- Keywords:
rabbits;
liver neoplasms;
embolization,therapeutic;
doxorubicin;
liposomes;
pharmacokinetics;
pharmacodynamics
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(2):127-130
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the pharmacokinetics and pharmacodynamics of doxorubicin hydrochloride liposomes combined with iodized oil in hepatic artery embolization of rabbit VX2 liver cancer.Methods Doxorubicin hydrochloride liposomes-lipiodol suspension were prepared at ratios of 1∶1,1∶2 and 2∶1,respectively,and the delamination time of each suspension was observed.Twenty New Zealand white rabbits were randomly divided into group A—D(each n=5).Doxorubicin hydrochloride liposomes-iodized oil emulsion was injected into group A,while doxorubicin hydrochloride-iodized oil emulsion was injected into group B for embolization of hepatic artery.Hepatic artery infusion was performed in group C with doxorubicin hydrochloride liposomes,while in group D with doxorubicin hydrochloride.The blood drug concentrations 1,4,8,12,16,20 and 24 h after treatments were compared among 4 groups.Another 20 healthy New Zealand white rabbits were modeling,and the rabbit models of VX2 liver cancer were randomly divided into experimental group and control group(each n=10).Doxorubicin hydrochloride liposomes-iodized oil emulsion was used in experimental group,while doxorubicin-iodized oil emulsion was used in control group for embolization of hepatic artery.The therapeutic effect was evaluated according to modified response evaluation criteria in solid tumors(mRECIST),and the objective response rate(ORR)and disease control rate(DCR)were recorded.Results Doxorubicin hydrochloride liposomes-lipiodol suspension with different proportions were all stratified within 1 min.Pharmacokinetic experiment showed that the blood drug concentration of group A and C were similar at each time point after treatment,and both higher than that in group B and D.Pharmacodynamics experiments showed that ORR and DCR in experimental group was 50.00%(5/10)and 90.00%(9/10),respectively,while in control group was 40.00%(4/10)and 80.00%(8/10),respectively.Conclusion Blood drug concentrations of doxorubicin hydrochloride were similar at each time point after hepatic artery embolization or hepatic artery infusion.Doxorubicin hydrochloride liposomes-iodized oil suspension had the same effect of doxorubicin-lipiodol emulsion for hepatic artery embolization of rabbit VX2 liver cancer.
