Intratumoral and peritumoral CT radiomics combined with clinic for predicting cervical lymph node metastasis of papillary thyroid carcinoma
10.13929/j.issn.1672-8475.2025.02.007
- VernacularTitle:瘤内及瘤周CT影像组学联合临床预测甲状腺乳头状癌颈部淋巴结转移
- Author:
Qi YAO
1
;
Qifeng LIU
1
;
Lei LYU
1
;
Chengmeng ZHANG
1
;
Zhimin DING
1
Author Information
1. 皖南医学院弋矶山医院放射科,安徽 芜湖 241001
- Publication Type:Journal Article
- Keywords:
thyroid neoplasms;
lymphatic metastasis;
tomography,X-ray computed;
radiomics
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(2):112-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of intratumoral and peritumoral CT radiomics combined with clinic for predicting cervical lymph node metastasis(CLNM)of papillary thyroid carcinoma(PTC).Methods Totally 338 patients with PTC were retrospectively enrolled and divided into training set(n=236)and validation set(n=102)at a ratio of 7∶3,also further assigned into subgroups according to CLNM or not within sets.The clinical independent risk factors for PTC CLNM were identified using multivariate logistic regression analysis,and a clinical model was then constructed.Intratumoral ROI were delineated on CT images including non-enhanced and three-phase enhancement images,which were then enlarged by 2 mm.Radiomics models of intratumoral,peritumoral and intratumoral+peritumoral ROI were established based on non-enhanced CT,as well as arterial phase,venous phase,delayed phase and multi-phase enhanced CT,respectively,the best one was selected and combined with clinical model to construct a combined model.Receiver operating characteristic curve was drawn,and the area under the curve(AUC)was calculated to evaluate the efficacy of each model for predicting PTC CLNM.Results Male patient and aged＜45 years were both clinical independent risk factors for PTC CLNM(both P＜0.05).Multi-phase intratumoral+peritumoral radiomics model was the optimal radiomics model,which was used to construct the combined model combining with clinical model.The AUC of combined model for predicting PTC CLNM in training set was 0.859,superior to that of clinical model and multi-phase intratumoral+peritumoral radiomics model(0.684,0.831,both P＜0.05),which in validation set was 0.832,similar to that of multi-phase intratumoral+peritumoral radiomics model(0.819,P=0.368)but superior to that of clinical model(0.605,P＜0.001).Conclusion Multi-phase intratumoral and peritumoral CT radiomics could be used to predict PTC CLNM.Combining with clinic could further improve its efficacy.
