Changes of neutrophil-to-lymphocyte ratio before and after the first interventional treatment of hepatocellular carcinoma for predicting patient's overall survival
10.13929/j.issn.1672-8475.2025.02.002
- VernacularTitle:首次介入治疗肝细胞癌前、后中性粒细胞与淋巴细胞比值变化预测患者总生存期
- Author:
Xiaosong TAN
1
;
Duanming DU
1
;
Zhenpeng ZENG
1
;
Ying WU
1
;
Chenjie XIAO
1
;
Huan MA
1
;
Yumin WU
1
;
Chunlin LIU
1
;
Yuefei HONG
1
Author Information
1. 深圳大学第一附属医院 深圳市第二人民医院介入治疗科,广东 深圳 518000
- Publication Type:Journal Article
- Keywords:
carcinoma,hepatocellular;
neutrophils;
lymphocytes;
survival;
hemoembolization,therapeutic
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(2):86-90
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of changes of neutrophil-to-lymphocyte ratio(NLR)before and after the first interventional treatment of hepatocellular carcinoma(HCC)for predicting patient's overall survival(OS).Methods Totally 92 HCC patients who underwent the first time TACE or TACE+hepatic artery infusion chemotherapy(HAIC)were retrospectively enrolled.The patients were divided into NLR ratio(NLRR)＜1.29 group(n=54)and≥1.29 group(n=38)based on the ratio of NLR after to before treatment,also ΔNLR＜0.87 group(n=60)and≥0.87 group(n=32)based on the difference of NLR after and before treatment.Clinical data were compared between groups,survival analysis was performed,and the value of NLRR and ΔNLR for predicting OS were analyzed.Results No significant difference of clinical data was found between NLRR＜1.29 and≥1.29 groups,nor between ΔNLR＜0.87 and≥0.87 groups(all P＞0.05).The median OS of 92 patients was 30.90 months,which in NLRR＜1.29 group(55.10 months)was longer than that in NLRR≥1.29 group(22.30 months,P=0.005),while in ΔNLR＜0.87 group(55.10 months)was longer than that in ΔNLR≥0.87 group(14.20 months,P=0.003).Cox regression analysis showed that the maximum diameter of tumor≥5 cm,distant metastasis,ascites,NLRR≥1.29 and ΔNLR≥0.87 were all independent risk factors of OS(all P＜0.05).Taken 1.29 and 0.87 as the best cut-off value,respectively,the area under the curve of NLRR and ΔNLR for predicting OS was 0.620 and 0.610,respectively.Conclusion NLRR and ΔNLR were helpful for predicting OS of HCC patient after the first interventional treatment.
