Predictive value of atherogenic index of plasma index,triglyceride-glucose index and cerebral small vascular disease imaging markers on early neurological response after intravenous thrombolysis in patients with acute ischemic stroke
10.3969/j.issn.1006-7795.2025.01.008
- VernacularTitle:血浆致动脉粥样硬化指数、三酰甘油-葡萄糖指数、脑小血管病影像学标志物对急性缺血性脑卒中患者静脉溶栓早期神经功能恢复的预测价值
- Author:
Xiao YANG
1
;
Yuanyuan MENG
;
Jingyi YANG
;
Shuhan WANG
;
Ligong ZHANG
Author Information
1. 山东第二医科大学临床医学院,山东潍坊 261053
- Publication Type:Journal Article
- Keywords:
acute ischemic stroke;
early prognosis;
atherogenic index of plasma;
triglyceride-glucose index;
small vascular disease imaging burden
- From:
Journal of Capital Medical University
2025;46(1):48-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of the atherogenic index of plasma(AIP),triglyceride-glucose(TyG)index,and cerebral small vascular disease(CSVD)imaging load score regarding the early prognosis of patients with acute ischemic stroke(AIS)after intravenous thrombolysis.Methods A total of 379 inpatients diagnosed with AIS at the Shengli Oilfield Central Hospital and treated with intravenous thrombolysis from January 2022 to December 2023 were retrospectively analyzed.Relevant data were collected,and the CSVD imaging load score was evaluated.The patients were classified into the good prognosis group(≥18％)and the poor prognosis group(＜18％)based on the early neurological improvement rate 14 d after thrombolysis.An investigation into the independent risk factors influencing the early prognostic outcomes in patients suffering from AIS was conducted utilizing binary Logistic regression analysis.The efficacy of early prognosis prediction in patients undergoing intravenous thrombolysis was assessed through receiver operating characteristic(ROC)curve analysis.Results Systolic blood pressure,AIP,TyG index,neutrophil to lymphocyte ratio(NLR),cerebral microbleeds(CMB),enlarged perivascular spaces(EPVS)and a CSVD imaging load score of 2 points or higher served as independent risk factors influencing the early prognosis in AIS patients undergoing thrombolysis.The ROC curve analysis revealed that the area under the curve(AUC)for the CSVD imaging load score was 0.821,with a sensitivity of 80.4％and a specificity of 74％.The AUC of the AIP was 0.951,with a sensitivity of 89.2％and a specificity of 91.7％.The AUC of the TyG index was 0.918,with a sensitivity of 93.1％and a specificity of 82.7％.Conclusions The AIP,TyG index,and CSVD imaging load score serve as efficacious indicators in assessing the premature prognostication of AIS patients who underwent subsequently to intravenous thrombolytic therapy.
