Research progress on activated leukocyte adhesion molecules in lupus nephritis
10.3969/j.issn.1006-7795.2025.01.023
- VernacularTitle:活化的白细胞黏附分子在狼疮性肾炎中的研究进展
- Author:
Kexia WENG
1
;
Bing LI
Author Information
1. 海南医科大学第二附属医院肾病内科,海口 571199
- Publication Type:Journal Article
- Keywords:
lupus nephritis;
activated leukocyte cell adhesion molecule;
biomarkers;
therapeutic targets
- From:
Journal of Capital Medical University
2025;46(1):150-153
- CountryChina
- Language:Chinese
-
Abstract:
Lupus nephritis(LN)is a common and serious complication of systemic lupus erythematosus(SLE).The clinical course of LN is usually characterized by alternating phases of remission and exacerbation.The onset of LN can lead to deterioration of renal function and requires prompt diagnosis and treatment.Some studies have suggested that the presence and changes of activated leukocyte cell adhesion molecule(ALCAM)may be related to the development of LN as well as LN activity.Urinary activated leukocyte cell adhesion molecule(uALCAM)is promising as a non-invasive marker for evaluating LN activity in SLE patients.Determination of uALCAM levels is helpful in early diagnosis,indication of disease activity and prediction of disease recurrence.ALCAM is expressed in a variety of cells and exerts different biological effects,including regulating cell differentiation,proliferation and migration.It is also pathologically expressed in various malignant tumors and has carcinogenic properties.This review will review the existing research on the role of ALCAM in the genesis and progression of LN,and the potential role of ALCAM as a new diagnostic marker and therapeutic target.
