Differential diagnosis between gastric poorly cohesive carcinoma and tubular adenocarcinoma based on spectral CT multi-parameters and clinical features
10.3969/j.issn.1002-1671.2025.02.014
- VernacularTitle:基于光谱CT多参数及临床特征鉴别胃低黏附性癌与管状腺癌
- Author:
Xiaoying TAN
1
;
Zhou LU
;
Zongqiong SUN
;
Xiao YANG
;
Zhendong WU
;
Shudong HU
;
Linfang JIN
Author Information
1. 江南大学附属医院影像科,江苏 无锡 214000;浙江大学医学院附属邵逸夫医院放射科,浙江 杭州 310000
- Publication Type:Journal Article
- Keywords:
gastric cancer;
spectral CT;
poorly cohesive carcinoma;
tubular adenocarcinoma
- From:
Journal of Practical Radiology
2025;41(2):241-245
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a combined model of spectral CT multi-parameters and clinical features to distinguish between gastric poorly cohesive carcinoma and tubular adenocarcinoma.Methods A total of 87 patients with gastric cancer confirmed by postoperative pathology were retrospectively selected,including 26 patients with poorly cohesive carcinoma and 61 patients with tubular adenocarcinoma.Predictors were identified by univariate and multivariate logistic regression analyses,and a combined model was established.The area under the curve(AUC)of receiver operating characteristic(ROC)curve was used to evaluate the differential diagnostic efficiency of the parameters and the model.The AUC was compared by DeLong method.Results The gender[odds ratio(OR)5.124,P=0.004],normalized iodine density in the arterial phase(nIoDAP)(OR 5.789,P=0.017),arterial enhancement fraction(AEF)(OR 7.007,P=0.002)and ΔIoD(OR 0.025,P=0.021)were identified as independent predictors for poorly cohesive carcinoma by logistic regression analysis.The AUC of combined model established by four variables in distinguishing poorly cohesive carcinoma and tubular adenocarcinoma was 0.837[95％confidence interval(CI)0.716-0.907],which was significantly higher than that of single tumor spectral CT parameters(P＜0.01).Conclusion The combined model based on patients'gender and tumor spectral CT parameters(nIoDAP,AEF and ΔIoD)can effectively distinguish gastric poorly cohesive carcinoma and tubular adenocarcinoma,providing a basis for gastric cancer patients'individualized treatment strategy.
