Effect of rs28362491 polymorphism in NF-κB1 gene on the efficacy of atorvastatin
10.3969/j.issn.1673-9701.2025.14.003
- VernacularTitle:NF-κB1基因rs28362491位点多态性对阿托伐他汀疗效的影响
- Author:
Chao LI
1
;
Yun CHEN
1
;
Ruyou TONG
1
;
Xiaosheng SHENG
1
Author Information
1. 金华市人民医院心血管内科,浙江 金华 321002
- Publication Type:Journal Article
- Keywords:
Gene polymorphism;
Coronary heart disease;
Atorvastatin;
Blood lipid
- From:
China Modern Doctor
2025;63(14):11-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of polymorphism at the-94ins/del ATTG(rs28362491)site in the promoter region of nuclear transcription factor-κB(NF-κB)1 on the lipid-lowering and anti-inflammatory efficacy of atorvastatin in patients with coronary heart disease(CHD).Methods A total of 180 patients with CHD in Jinhua People's Hospital from June 2022 to June 2024 were selected as the research objects.The genotypes of rs28362491 locus of NF-κB1 gene were detected.The levels of blood lipids and inflammatory factors before treatment,1 month and 6 months after treatment were analyzed,and the incidence of adverse reactions during treatment were observed.Results A total of 180 CHD patients underwent genetic testing and were divided into DD genotypes 46 cases,ID genotypes 76 cases,and II genotypes 58 cases.The levels of total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),interleukin(IL)-6,IL-8,and tumor necrosis factor-α(TNF-α)in DD genotypes were higher than those in ID genotypes and Ⅱ genotypes(P<0.05).After 1month and 6 months treatment,the levels of TC,LDL-C,IL-6,IL-8,and TNF-α in three groups of patients decreased significantly compared to before treatment(P<0.05).At the same time point,the change rates of TC,LDL-C,IL-6,IL-8,and TNF-α levels in ID genotypes and Ⅱgenotypes were higher than those in DD genotypes(P<0.05).Conclusion The efficacy of atorvastatin in CHD patients is associated with the rs28362491 polymorphism of the NF-κB1 gene,with II genotypes and ID genotypes showing better efficacy than DD genotypes.
