Volume changes in the thalamus and thalamic subnucleus in patients with trigeminal neuralgia
10.3969/j.issn.1002-1671.2025.02.005
- VernacularTitle:三叉神经痛患者的丘脑及丘脑亚核体积改变
- Author:
He ZHAO
1
;
Shenghui XIE
;
Xueying MA
;
Qiong WU
;
Xue BAI
;
Yang GAO
Author Information
1. 内蒙古医科大学附属医院放射科,内蒙古 呼和浩特 010030
- Publication Type:Journal Article
- Keywords:
trigeminal neuralgia;
chronic pain;
magnetic resonance imaging
- From:
Journal of Practical Radiology
2025;41(2):198-201
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the thalamus and thalamic subnucleus volume changes in patients with trigeminal neuralgia(TN)and to preliminarily investigate whether there is a pain processing lateralization advantage in the thalamus.Methods The three-dimensional T1WI images of 56 TN patients and 56 matched healthy controls(HC)were collected,and thalamus and thalamic subnucleus volumes were extracted by automated segmentation via a region of interest(ROI)-based morphological analysis method.Results There was no significant difference in the whole thalamus volume between TN and HC groups.Compared with HC,the bilateral ventral lateral(VL)of the thalamus were significantly smaller in patients with right-sided trigeminal neuralgia(RTN),and no significant thalamic subnucleus volume changes were found in patients with left-sided trigeminal neuralgia(LTN).After mirror-flipping the whole-brain images of the LTN,it was found that the volume of ipsilateral thalamic VL of TN group was significantly reduced than that of HC group.The volume of ipsilateral mediodorsal lateral parvocellular(MD1)of TN group was significantly smaller than that of HC group.There was no significant difference in the volume of ipsilateral and contralateral thalamic subnucleus.Conclusion The thalamic subnucleus are exclusively reduced in volume in patients with TN,and there is no significant change in whole thalamus volume,suggesting no lateralization advantage for pain processing.
