Clinical effects of Heiguteng Zhuifeng Huoluo Capsules combined with warm acupuncture at musculotendinous pathological nodes on patients with knee osteoarthritis due to Cold-Dampness Obstruction and Fixed Impediment
10.3969/j.issn.1001-1528.2025.05.015
- VernacularTitle:黑骨藤追风活络胶囊联合结筋病灶点温针灸对寒湿痹阻型膝骨关节炎患者的临床疗效
- Author:
Jing DAN
1
;
Hua DING
;
Gang WANG
;
Jia-hao WANG
;
Shao-hua JU
;
Huai-min LU
Author Information
1. 成都体育学院附属体育医院运动医学康复科,四川成都 610000
- Publication Type:Journal Article
- Keywords:
Heiguteng Zhuifeng Huoluo Capsules;
warm acupuncture;
musculotendinous pathological nodes;
Celecoxib Capsules;
knee osteoarthritis;
Cold-Dampness Obstruction and Fixed Impediment
- From:
Chinese Traditional Patent Medicine
2025;47(5):1514-1519
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the clinical effects of Heiguteng Zhuifeng Huoluo Capsules combined with warm acupuncture at musculotendinous pathological nodes on patients with knee osteoarthritis due to Cold-Dampness Obstruction and Fixed Impediment.METHODS One hundred and sixty patients were randomly assigned into control group(80 cases)for 4-week intervention of both warm acupuncture at musculotendinous pathological nodes and Celecoxib Capsules,and observation group(80 cases)for 4-week intervention of Heiguteng Zhuifeng Huoluo Capsules,warm acupuncture at musculotendinous pathological nodes and Celecoxib Capsules.The changes in clinical effects,TCM syndrome scores,WOMAC scores,Lequesne indices,pain mediators(PGE2,β-EP),growth factors(TGF-β1,IGF-1),bone metabolism indices(OPG,RANKL),TLR4/NF-κB signaling pathway and safety indices were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,WOMAC scores,Lequesne indices,PGE2,RANKLE,TLR4,NF-κB(P＜0.05),and increased β-EP,growth factors,OPG(P＜0.05),especially for the observation group(P＜0.05).No serious adverse events or reactions were observable in the two groups.CONCLUSION For the patients with knee osteoarthritis due to Cold-Dampness Obstruction and Fixed Impediment,Heiguteng Zhuifeng Huoluo Capsules combined with warm acupuncture at musculotendinous pathological nodes can safely and effectively alleviate clinical symptoms,improve knee joint pain,and enhance joint functions,whose action mechanisms may contribute to the inhibition of TLR4/NF-κB signaling pathway expression and regulations of serum TGF-β1,IGF-1,OPG,RANKL levels.
