Relationship between leukoaraiosis and cerebrovascular reserve in elderly rheumatoid arthritis with cognitive impairment
10.3969/j.issn.1002-1671.2025.02.001
- VernacularTitle:老年类风湿关节炎患者认知功能障碍与脑白质疏松及脑血管储备的关系
- Author:
Yongku DU
1
;
Lin QIAO
;
Juan LI
;
Zhonghui SUN
;
Yafeng SHI
;
Xin JING
;
Chao LI
;
Jun YAN
Author Information
1. 西安市第五医院影像科,陕西 西安 710082
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
cognitive impairment;
leukoaraiosis;
cerebrovascular reactivity
- From:
Journal of Practical Radiology
2025;41(2):181-185
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between cognitive function changes and leukoaraiosis(LA)and cerebrovascular reserve(CVR)in elderly patients with rheumatoid arthritis(RA).Methods A total of 160 elderly patients with RA were selected and their cognitive function were also evaluated.Based on the scoring results of Montreal cognitive assessment(MoCA),all patients were categorized into normal cognitive function group[non cognitive impairment(CI)group]and CI group,respectively.The general clinical information of the patients were recorded,LA via head MRI were evaluated,and CVR through breath holding index(BHI)were assessed,respectively.The relevant risk factors of the two groups of RA patients were analyzed,and univariate and multivariate logistic regression analyses were used to screen the independent risk factors for cognitive decline in elderly patients with RA,and the predictive efficacy of LA score and BHI in the two groups of patients were compared,respectively.Results There were significant differences in education level,coronary heart disease,diabetes,disease activity score(DAS28 score),BHI and LA score between the two groups(P＜0.05).Multivariate logistic regression results displayed that BHI and LA score were independent risk factors for cognitive decline.The receiver operating characteristic(ROC)curve suggested that BHI had a higher predictive value for cognitive decline in elderly RA patients.Conclusion The LA score of elderly RA patients with CI increases while BHI significantly decreases.BHI has a high diagnostic value in predicting cognitive decline in elderly RA patients.
