Correlation between MRI burden and inflammatory factors and depression in elderly patients with cerebral small vessel disease
10.3969/j.issn.1004-1648.2025.01.006
- VernacularTitle:老年患者脑小血管病MRI负荷程度及炎症因子与抑郁的相关性
- Author:
Hongge JI
1
;
Tingting WANG
;
Yingying LI
Author Information
1. 233030 蚌埠医科大学研究生院
- Publication Type:Journal Article
- Keywords:
cerebral small vessel disease;
MR1 burden degree;
inflammatory factors;
depression
- From:
Journal of Clinical Neurology
2025;38(1):23-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the corr-elation between MRI burden and inflammatory factors and depression in elderly patients with cerebral small vessel disease(CSVD).Methods The clinical data of 150 patients with CSVD confirmed by brain MRI(CSVD group)and 40 patients with normal brain MRI(control group)were collected.The Hamilton depression rating scale 17-item(HAMD-17)was used to evaluate the degree of depression of the patients.The differences in CSVD burden,inflammatory markers and risk factors between the depressed group and the non-depressed group were compared,and the predictive value of the three and their combined predictions on depression were analyzed.The difference and correlation of HAMD-17 item scale scores between control group and CSVD group were compared.Results There were statistically significant differences in women,stress level,and high-sensitivity C-reactive protein(hs-CRP)level between the depressed group and the non-depressed group(all P＜0.05).Logistic regression analysis showed that CSVD burden degree,female,and hs-CRP were independent risk factors for depression(all P＜0.05).The ROC curve showed that the cut-off value of CSVD burden for depression was moderate,the sensitivity was 73％,the specificity was 47％,and the area under the curve(AUC)was 0.648(95％CI:0.558-0.738,P=0.002);the cut-off value of hs-CRP for depression was 3.73 mg/L,the sensitivity was 60％,the specificity was 73％,and the AUC area was 0.657(95％CI:0.566-0.748,P=0.001);the sensitivity of gender to depression was 68％,the specificity was 52％,and the AUC area was 0.597(95％CI:0.505-0.690,P=0.045).The combined sensitivity and specificity of the three were 70％and 73％,and the AUC area was 0.738(95％CI:0.656-0.820,P＜0.001).Compared with that in the control group,the HAMD-17 score of patients in the mild,moderate and severe burden groups were significantly increased(H=21.854,P＜0.001).Spearman correlation analysis showed that CSVD burden was positively correlated with HAMD-17 score(r=0.330,P＜0.001).Conclusions CSVD burden,female and elevated hs-CRP are independent risk factors for depression in elderly patients with CSVD.The degree of CSVD burden is positively correlated with depression score,and the accuracy of the combined prediction model is high,which has certain predictive value for senile depression.
