Dosimetric study of undergoing pelvic protection for patients with cervical cancer based on two kinds of rotational irradiation modes
10.3969/j.issn.1672-8270.2025.03.005
- VernacularTitle:基于两种旋转照射模式下宫颈癌患者行骨盆保护的剂量学研究
- Author:
Hao QIU
1
;
Feifei ZHANG
;
Chun BI
;
Tianhong TANG
;
Wenjing LI
;
Shancheng SHI
;
Jiajia WANG
;
Qianjin SHI
Author Information
1. 宿迁市泗阳医院肿瘤放疗中心 宿迁 223700
- Publication Type:Journal Article
- Keywords:
Cervical cancer;
Intensity modulated radiotherapy(IMRT);
Rotational irradiation modes;
Dosimetry;
Bone marrow depression
- From:
China Medical Equipment
2025;22(3):22-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the dosimetric differences between volumetric modulated arc therapy(VMAT)and helical tomotherapy(HT)in undergoing protective plan for pelvic bones of patients with cervical cancer.Methods:A total of 40 patients with cervical cancer,who underwent radiotherapy at the First Affiliated Hospital of Bengbu Medical University from January 2023 to February 2024,were selected for this study.The target volumes and organs at risk(OARs)were delineated after the information of computed tomography(CT)simulation images were acquired from each patient.The pelvic bone was alone delineated as OAR.Two kinds of bone marrow dose-limiting radiotherapy plans,coplanar dual-arc VMAT and HT,were respectively designed for each patient by using the treatment planning system(TPS)of radiotherapy.A statistical analysis was conducted to compare the dose parameters of target volume,conformity,homogeneity,OAR dose-volume,mean dose,and maximum dose of point between the two kinds of plans.Results:Both the VMAT and HT plans could meet the requirements of target volume and OARs for dose.For general OARs,the dose-volume percentage(V40 Gy)of V40 Gy at bladder,mean dose(Dmean),rectal V40 Gy,maximum dose(Dmax)at small intestine point of HT plan were respectively(38.97±2.29)%,(38.06±0.45)Gy,(61.50±2.51)%and(50.82±0.36)Gy.The differences of them between HT plan and VMAT plan were statistically significant(t=25.46,13.99,1.56,10.93,P<0.05).The V10 Gy,V20 Gy,V30 Gy and Dmean of VMAT plan were respectively(70.76±2.51)%,(60.84±3.29)%,(52.40±2.56)%and(32.02±4.33)Gy for pelvic bones,which were significantly lower than those of HT plan,and the differences of them between two kinds of plans were also statistically significant(t=-20.68,-13.23,-7.73,-10.26,P<0.05).Conclusion:The HT plan can provide the optimal dose distribution for target region in radiotherapy for patients with cervical cancer,which can better protect OAR nearby target region.VMAT plan has a significant advantage in low-dose regions of protecting pelvis.Thus,individualized treatment design should be conducted according to the conditions of each patient in clinical treatment.
