Effects of Inonotus obliquus polysaccharides on main organs and hormones in male mice infected with Neospora caninum
10.16303/j.cnki.1005-4545.2025.02.11
- VernacularTitle:桦褐孔菌多糖对新孢子虫感染雄鼠主要脏器组织和激素的影响
- Author:
Meng LIU
1
;
Sicheng LIN
1
;
Fanglin ZHAO
1
;
Zhenyu WANG
1
;
Yang WANG
1
;
Pengfei MIN
1
;
Lu LI
1
;
Lijun JIA
1
Author Information
1. 延边大学农学院东北寒区肉牛科技创新教育部工程研究中心,吉林延吉 133000
- Publication Type:Journal Article
- Keywords:
Inonotus obliquus polysaccharide;
Neosporosis;
organs;
pathology;
hormone;
mice
- From:
Chinese Journal of Veterinary Science
2025;45(2):249-254
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study is to determine the effects of Inonotus obliquus polysaccharides on the main organs and hormones of male mice infected with Neosporidium.The animal model of neosporidiosis in BALB/c mice was established.After intragastric administration,the pathological changes of brain,liver and spleen were observed by histopathology,the worm load in brain,liver and spleen was detected by qPCR,and the levels of FSH,LH and T4 in serum of male mice were detected by ELISA.The results showed that compared with the blank control group,granular spherical lesions could be seen in the brain tissue of mice in the model group,with patchy necrosis of hepatocytes,splenic hemorrhage,red pulp hyperemia and a large number of red blood cell infil-tration.Inonotus obliquus polysaccharides can improve the injury of brain,liver,spleen and other organs and tissues.The worm load in the brain of the Inonotus obliquus polysaccharide group was significantly lower than that of the model group on the 14th day and 21st day(P＜0.01),and that of the liver and spleen on the 21st day was significantly lower than that of the model group(P＜0.01).The level of FSH in the model group and Inonotus obliquus polysaccharide group was signif-icantly lower than that in the blank control group(P＜0.05 or P＜0.01),while that in the Inono-tus obliquus polysaccharide group was significantly higher than that in the model group(P＜0.05 or P＜0.01).The level of LH in the model group was significantly higher than that in the blank control group(P＜0.01),while that in the Inonotus obliquus polysaccharide group was significant-ly higher than that in the blank control group on the 7th day and 42nd day(P＜0.05).There was significant difference in T4 level between the model group and the blank group(P＜0.05 or P＜0.01),while the Inonotus obliquus polysaccharide group was similar to the blank control group on the 21st and 35th day(P＞0.05).Inonotus obliquus polysaccharides can improve the damage of Neosporidium on brain,liver and spleen of male rats,reduce the insect load in brain,liver and spleen,regulate the levels of FSH,LH and T4 hormones,and maintain the stability of reproductive system.
