Magnetic resonance imaging features and early efficacy prediction of mediastinal T-lymphoblastic lymphoma in children and adolescents
10.3760/cma.j.cn101070-20250122-00053
- VernacularTitle:儿童及青少年纵隔T淋巴母细胞淋巴瘤磁共振成像特征及早期疗效预测
- Author:
Lidan ZHOU
1
;
Bingjie ZHENG
;
Yuxia LI
;
Yang LI
;
Bo HU
;
Yonghong ZHANG
;
Changhong ZHAO
;
Jiajun ZHANG
;
Hongwei XU
Author Information
1. 郑州大学第五附属医院医学影像科，郑州 450008
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Diffusion-weighted imaging;
Apparent diffusion coefficient;
T-lymphoblastic lymphoma;
Treatment response
- From:
Chinese Journal of Applied Clinical Pediatrics
2025;40(4):283-289
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the magnetic resonance imaging (MRI) features of pediatric and adolescent mediastinal T-lymphoblastic lymphoma (T-LBL) and to evaluate their predictive value for early treatment response.Methods:A retrospective, multicenter case series study was conducted on 49 pediatric and adolescent patients diagnosed with mediastinal T-LBL between September 2020 and May 2024 at the Fifth Affiliated Hospital of Zhengzhou University, Beijing Gaobo Boren Hospital, and Henan Cancer Hospital.All patients underwent chest MRI, including conventional MRI sequences and diffusion-weighted imaging.Tumor imaging characteristics were analyzed, and quantitative parameters such as minimum apparent diffusion coefficient (ADCmin), maximum ADC (ADCmax), and mean ADC (ADCmean) were measured.Treatment response was evaluated 15 days post-treatment.The patients were divided into a response group (complete or partial response, 26 cases) and a non-response group (progressive disease or minor response, 23 cases).The relationship between MRI features and treatment response was analyzed.The intraclass correlation coefficient was used to assess inter-reader agreement, and independent sample t-tests and chi-square tests were employed to compare differences between groups.Receiver operating characteristic (ROC) curve analysis was conducted to evaluate the predictive performance of imaging parameters. Results:Significant differences were observed between the response and non-response groups in ADC values [ADCmin (0.80±0.41)×10 -3 mm 2/s vs.(1.23±0.70)×10 -3 mm 2/s, ADCmax (1.14±0.48)×10 -3 mm 2/s vs.(1.92±0.77)×10 -3 mm 2/s, ADCmean (0.98±0.42)×10 -3 mm 2/s vs.(1.56±0.74)×10 -3 mm 2/s] and the maximum tumor diameter was [(11.92±3.61) cm vs.(8.17±2.46) cm] (all P<0.05).ROC curve analysis showed that ADCmax had the highest predictive efficiency for treatment response, with an area under the curve (AUC) of 0.853 (95% CI: 0.790-0.910), sensitivity of 92.3%, and specificity of 65.2%.The AUC for the maximum tumor diameter was 0.814, demonstrating its excellent predictive performance. Conclusions:MRI features, particularly ADC values and the maximum tumor diameter, can effectively predict treatment response in pediatric and adolescent mediastinal T-LBL.
