Advances in diagnosis and treatment of congenital hyperinsulinism in children
10.3760/cma.j.cn101070-20240612-00364
- VernacularTitle:儿童先天性高胰岛素血症的诊疗进展
- Author:
Ming CHENG
1
;
Dongmei WANG
1
;
Chang SU
1
;
Chunxiu GONG
1
Author Information
1. 国家儿童医学中心，首都医科大学附属北京儿童医院内分泌遗传代谢科，北京 100045
- Publication Type:Journal Article
- Keywords:
Child;
Hypoglycemia;
Congenital hyperinsulinism
- From:
Chinese Journal of Applied Clinical Pediatrics
2025;40(4):308-312
- CountryChina
- Language:Chinese
-
Abstract:
Congenital hyperinsulinism is the most common cause of hypoglycemia in children, characterized by a complex genetic basis, diverse pathogenic mechanisms, and significant clinical heterogeneity.Delayed diagnosis and treatment can lead to irreversible neurological sequelae, including epilepsy and psychomotor retardation.In this review, recent advancements in the molecular genetics, imaging localization, therapeutic strategies, and follow-up outcomes of congenital hyperinsulinism were summarized so as to offer valuable insights for its clinical management.
