Current status of research on the application of non-invasive or minimally invasive methods to predicting the prognosis of biliary atresia after Kasai portoenterostomy
10.3760/cma.j.cn101070-20240407-00207
- VernacularTitle:利用无创、微创手段预测胆道闭锁Kasai肠吻合术后预后的研究现状
- Author:
Qinlu ZENG
1
;
Dayan SUN
;
Jinshi HUANG
Author Information
1. 江西省儿童医院新生儿外科，南昌 330006
- Publication Type:Journal Article
- Keywords:
Biliary atresia;
Biomarker;
Prognosis
- From:
Chinese Journal of Applied Clinical Pediatrics
2025;40(3):223-226
- CountryChina
- Language:Chinese
-
Abstract:
Biliary atresia (BA) is a serious neonatal disease, which can eventually develop into cholestatic cirrhosis due to inflammation and progressive fibrosis of bile ducts inside and outside the liver.Kasai portoenterostomy (KP) is the main management strategy of BA that can help children rebuild bile drainage channels.However, the progress of intrahepatic diseases will cause portal hypertension, liver fibrosis, end-stage liver disease and other complications to varying degrees after KP in children, affecting their short-term and long-term prognosis and health.It is also possible that children need liver transplantation within one year after operation.At present, there is no consensus strategy for the prediction of the prognosis of KP in clinical practice.There is a need to find a reliable non-invasive method with high sensitivity and specificity to predict the prognosis after KP.Recently, many examination strategies have been proposed for predicting the prognosis after KP.In this paper, these non-invasive or minimally invasive methods were reviewed according to the source of predictors.
