Clinical characteristics, diagnosis, treatment and prognosis of neonatal hyperthyroidism
10.3760/cma.j.cn101070-20240713-00440
- VernacularTitle:新生儿甲状腺功能亢进症的临床特点与诊治转归
- Author:
Hongyi LI
1
;
Xinjiang HUANG
1
;
Xiaojian MAO
1
Author Information
1. 广州医科大学附属妇女儿童医疗中心遗传与内分泌科，广州 510623
- Publication Type:Journal Article
- Keywords:
Infant, newborn;
Hyperthyroidism;
Antithyroid-drugs;
Thyroid stimulating hormone receptor antibody
- From:
Chinese Journal of Applied Clinical Pediatrics
2025;40(2):97-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze and summarize the clinical characteristics, diagnosis, treatment, and prognosis of 27 cases of neonatal hyperthyroidism (NH).Methods:A case summary was made.The clinical data of children who were diagnosed with NH and treated at Guangzhou Women and Children′s Medical Center, Guangzhou Medical University from January 2018 to December 2023 were collected and retrospectively analyzed.Results:A total of 27 NH children were included.Only 1 child′s mother had normal thyroid function, and the mothers of the remaining 26 children had a history of hyperthyroidism before or during pregnancy.The median diagnosis time was 12 days after birth (4-42 days).The main clinical manifestations were tachycardia (20 cases) and excitement (6 cases).However, the family members of 16 children (59.26%) felt asymptomatic.These children were recalled due to positive results of neonatal screening or abnormal thyroid function detected in their mothers during pregnancy.Then they perfected a thyroid function test and were diagnosed with NH.Tachycardia was detected in 9 of the 16 children at presentation, and nothing abnormal was found in the remaining 7 children.Twenty children were treated with Methimazole (MMI).The median MMI use time was 53 days (6-264 days), and the time for thyroid function to return to normal was 76.5 days (44.0-209.0 days).Twelve children were followed up after recovery of thyroid function, and 1 case of them was diagnosed with physical stunting, 4 cases were diagnosed with development delay, and 1 case had premature fusion of bregma.Conclusions:The history of thyroid disease in pregnant mothers is very important for NH diagnosis, and neonates with family history of thyroid disease should be followed up.Moreover, the thyroid stimulating hormone receptor antibody should be dynamically monitored in pregnant mothers and neonates.It will contribute to the prediction and early treatment of NH, thereby preventing adverse outcomes.
