Discussion on the Pathogenesis and Treatment of Knee Osteoarthritis from the Theory of"Deficient Qi Stagnation"Based on Mitophagy
10.19879/j.cnki.1005-5304.202408093
- VernacularTitle:基于线粒体自噬从"虚气留滞"理论探讨膝骨关节炎病机与治疗
- Author:
Zifeng YE
1
;
Gaoyan KUANG
;
Yiwei YUAN
;
Liguo QIU
;
Xiaotong XU
;
Zhi WEN
;
Min LU
Author Information
1. 湖南中医药大学,湖南 长沙 410208;湖南中医药大学第一附属医院,湖南 长沙 410007
- Publication Type:Journal Article
- Keywords:
deficient qi stagnation;
mitochondria;
mitophagy;
knee osteoarthritis;
TCM theories
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(8):14-18
- CountryChina
- Language:Chinese
-
Abstract:
Mitophagy,a critical regulator of knee joint homeostasis,its dysfunction can lead to pathological changes such as reactive oxygen species overproduction,calcium ion overload,and extracellular matrix degradation,inducing cartilage degeneration and serving as a key pathological mechanism of knee osteoarthritis(KOA)."Deficient qi stagnation"represents the core pathogenesis of KOA.Mitochondria,analogous in function to qi and serving as its microscopic manifestation,exhibit a high degree of congruence between mitophagy and the defensive functions of qi.Based on the pathogenic characteristics of"deficient qi stagnation"of KOA,and integrating modern medical explanations of mitophagy,this article believed that the deficiency of liver,spleen and kidney qi is the fundamental reason for the imbalance of mitochondrial autophagy in KOA,and the retention of pathogenic toxins is the key factor in the imbalance of mitochondrial autophagy.The basic treatment method of tonifying qi and strengthening the body,promoting blood circulation and promoting stagnation can provide clinical formula ideas for the TCM prevention and treatment of KOA.
