Study on Intervention of Liuwei Dihuang Capsules on Intestinal Flora of Type 2 Diabetes Mellitus with Yin Deficiency Syndrome
10.19879/j.cnki.1005-5304.202409366
- VernacularTitle:六味地黄胶囊对2型糖尿病阴虚证肠道菌群的干预研究
- Author:
Dechao SONG
1
;
Xingzhong FENG
;
Xiaoyu CHEN
;
Xiaolong RONG
;
Huijuan GAO
;
Jingni XU
;
Aijia SHEN
;
Xiaoqi QI
;
Jing LIU
;
Shidong WANG
Author Information
1. 清华大学玉泉医院(清华大学中西医结合医院),北京 100040
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
yin deficiency syndrome;
Liuwei Dihuang Capsules;
intestinal flora;
immune inflammation;
clinical study
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(8):139-145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of Liuwei Dihuang Capsules for type 2 diabetes mellitus(T2DM)with yin deficiency syndrome and the effects on intestinal flora and inflammatory factors.Methods Totally 60 patients of T2DM with yin deficiency syndrome in Dongzhimen Hospital of Beijing University of Chinese Medicine from September 2022 to June 2023 were selected as the study objects,and were divided into control group and observation group according to the method of block randomization,with 30 cases in each group.Both groups received basic treatment.The control group was given a simulated agent of Liuwei Dihuang Capsules,while the observation group was given Liuwei Dihuang Capsules.The treatment course for both groups was 4 weeks.Clinical efficacy,blood glucose levels[fasting plasma glucose(FPG),2-hour postprandial plasma glucose(2 hPG),glycated albumin(GA)],serum insulin levels[fasting insulin(FINS)and insulin resistance index(HOMA-IR)],changes in gut microbiota,and serum inflammatory cytokine levels[interleukin(IL)-6,tumor necrosis factor(TNF)-α]of both groups were compared.Results The total effective rate of the observation group(76.67%)was better than that of the control group(50.00%)(P<0.05).Compared with before treatment,the FPG,2 hPG,GA,FINS and HOMA-IR decreased in the observation group,while the FPG,2 hPG and FINS decreased in the control group(P<0.05);after treatment,the Shannon index of the observation group increased after treatment(P<0.05),and the diversity of the microbiota increased;the abundance of the microbial communities such as Coprococcus 3,Cutibacterium,Pseudomonas,Faecalibaculum,Dubosiella and Mucispirillum significantly increased(P<0.05);the abundance of Sphingomonas,Corynebacterium 1,Ileibacterium,Ruminiclostridium and other microbiota communities significantly decreased(P<0.05).Compared with before treatment,the levels of IL-6 and TNF-α in both groups were significantly reduced after treatment(P<0.01,P<0.05).After treatment,the levels of IL-6 and TNF-α in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Liuwei Dihuang Capsules can effectively reduce blood glucose levels in patients of T2DM with yin deficiency syndrome,improve insulin resistance,increase gut microbiota diversity,increase beneficial bacterial abundance,reduce harmful bacterial abundance,and alleviate inflammatory cytokine levels.
