Research progress in the study of melatonin in the treatment of sepsis
10.12092/j.issn.1009-2501.2025.01.014
- VernacularTitle:褪黑素在脓毒症治疗中的研究进展
- Author:
Nan LI
1
;
Wanchun TANG
;
Zhongqi ZHANG
;
Xiangrong ZUO
Author Information
1. 南京医科大学第一临床医学院,南京 210009,江苏
- Publication Type:Journal Article
- Keywords:
sepsis;
melatonin;
multiple organ dysfunction syndrome;
organ protection
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(1):118-124
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis poses a significant threat to hu-man health due to its widespread prevalence,high mortality rate,substantial treatment costs,and the absence of effective life-saving therapies.Melato-nin,a primary hormone regulating the circadian rhythm,has demonstrated potential as a promising therapeutic agent against sepsis.Its anti-inflamma-tory,antioxidant,immunomodulatory,mitochondri-al protective,and multi-organ protective effects are noteworthy.In this review,we summarize current research on the mechanisms of action and clinical efficacy of melatonin in sepsis treatment and multi-organ function preservation,aiming to offer new perspectives and support for sepsis research and therapy.
