Current clinical application and research progress of antiplatelet drugs
10.12092/j.issn.1009-2501.2025.01.011
- VernacularTitle:抗血小板药物临床应用现状及研发新进展
- Author:
Guanxing PAN
1
;
Pinfang HUANG
;
Dajun CHAI
;
Jing ZHANG
Author Information
1. 福建医科大学附属第一医院临床药理研究中心,福州 350005,福建;福建医科大学附属第一医院滨海院区国家区域医疗中心临床药理研究中心,福州 350212,福建
- Publication Type:Journal Article
- Keywords:
antiplatelet drug;
platelet receptor;
drug development;
clinical trial
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2025;30(1):91-99
- CountryChina
- Language:Chinese
-
Abstract:
Arterial thrombosis is a major cause of death in several cardiovascular diseases(CVDs),including coronary heart disease and stroke.Since platelets play a pivotal role in arterial thrombosis,antiplatelet drug is an important part of the clinical therapy of CVD patients.Currently,the long-term antithrombotic effect of the dual antiplatelet thera-py of P2Y12 antagonists combined with aspirin are showed to be effective.And αⅡbβ3 antagonists rep-resented by tirofiban are widely used for antiplate-let therapy in emergency surgery.However,the bleeding risk caused by antiplatelet therapy is a clinical issue that cannot be ignored.In order to provide a reference for further research on anti-platelet drugs,this article reviews the major tar-gets of antiplatelet drugs and the drugs that have been under clinical research in recent years.
