Effects of esketamine-mediated opioid-free anesthesia on delirium in elderly patients after hip replacement

VernacularTitle:艾司氯胺酮主导无阿片麻醉对老年患者全髋关节置换术术后谵妄的影响
Author: Hao HUA ¹ ; Teng HE ; Xin LI ; Xiaodong CHEN ; Zhenqing LIU ; Kun LIU ; Qi ZHANG ; Lin JIANG ; Cunming LIU ; Meng WANG ; Chun YANG
Author Information

1. 苏州大学附属无锡九院麻醉科,无锡 214062,江苏
Publication Type:Journal Article
Keywords: esketamine; opioid-free anesthesia; elderly patients; delirium; analgesia
From: Chinese Journal of Clinical Pharmacology and Therapeutics 2025;30(1):78-84
CountryChina
Language:Chinese
Abstract: AIM:To observe the effect of opioid-free anesthesia with esketamine on delirium after hip replacement surgery in elderly patients.METH-ODS:One hundred and fourteen elderly patients who underwent hip replacement were randomly di-vided into two groups:opioid-free anesthesia(OFA)group and opioid anesthesia(OA)group(n=57).During anesthesia induction and maintenance,es-ketamine was administered in OFA group,and that fentanyl and remifentanil were administered in OA group.Delirium was mainly recorded within 3 days after the surgeries,and the patients'delirium sta-tus was evaluated using the Chinese Revised Deliri-um Diagnostic Scale(CAM-CR).RESULTS:The pa-tients in OFA group had lower CAM-CR scores and delirium incidence compared to those in the OA group at 2 days after surgery.CONCLUSION:Opioid-free anesthesia based on esketamine can effective-ly reduce delirium after hip replacement in elderly patients.