Exploring the Clinical Efficacy of the Yushen Yangluan Formula in Treating Diminished Ovarian Reserve with Kidney Es-sence Deficiency Based on Mitochondrial Energy Metabolism and Oxidative Stress
10.14148/j.issn.1672-0482.2025.0109
- VernacularTitle:基于线粒体能量代谢及氧化应激探讨育肾养卵方治疗肾精亏虚型卵巢储备功能减退的临床研究
- Author:
Jiami HUANG
1
;
Lin ZHU
1
;
Li TAN
1
;
Kening GUO
1
;
Xiaochun SUN
1
;
Tingting ZHANG
1
Author Information
1. 上海中医药大学附属岳阳中西医结合医院,上海 200437
- Publication Type:Journal Article
- Keywords:
diminished ovarian reserve;
Yushen Yangluan Formula;
kidney essence deficiency type;
mitochondrial energy metabo-lism;
oxidative stress;
reactive oxygen species;
adenosine triphosphate;
clinical research
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2025;41(1):109-114
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the clinical efficacy of the Yushen Yangluan Formula in treating diminished ovarian reserve(DOR)with kidney essence deficiency based on mitochondrial energy metabolism and oxidative stress.METHODS A total of 70 pa-tients diagnosed with DOR due to kidney essence deficiency,who visited the gynecology department of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine from September 2023 to June 2024,were selected.The patients were randomly divided into two groups according to the random number table method.The treatment group(35 cases)received the Yushen Yangluan Formula,while the control group(35 cases)received a Chinese herbal placebo,with treatment lasting for 3 months,and during the treatment pe-riod,one case dropped out from each group.Antral follicle count(AFC),traditional Chinese medicine(TCM)syndrome scores,and serum levels of anti-Mullerian hormone(AMH),follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),re-active oxygen species(ROS),and adenosine triphosphate(ATP)levels were compared between the two groups.RESULTS After treatment,the TCM syndrome scores for kidney deficiency in both groups decreased compared to before treatment(P<0.05,P<0.01),with the experimental group showing greater improvement than the control group(P<0.01).Following treatment,the FSH levels in the experimental group decreased compared to before treatment(P<0.05),while AMH levels increased(P<0.05),and the antral follicle count(AFC)also increased significantly(P<0.01),with the experimental group outperforming the control group(P<0.05,P<0.01).After treatment,serum ROS levels in the experimental group decreased(P<0.01),and ATP levels increased(P<0.01),with the experimental group showing superior results compared to the control group(P<0.01).CONCLUSION Yushen Yangluan Formu-la can improve the ovarian function and TCM syndrome score of patients with DOR of kidney essence deficiency type,which may be re-lated to improving mitochondrial energy metabolism and reducing oxidative stress.
