Quality standard improvement of Dahuang Sodium Bicarbonate Tablets
10.3969/j.issn.1001-1528.2025.07.001
- VernacularTitle:大黄碳酸氢钠片质量标准完善
- Author:
Jing-hai CHEN
1
;
Hua-hua HUANG
;
Ya-li YANG
;
Ying-ying WANG
;
Xue-zi HE
Author Information
1. 厦门大学附属妇女儿童医院(厦门市妇幼保健院)药学部,福建厦门 361003;福建省高校人文社科研究基地传统本草文化传承研究中心,福建厦门 361023
- Publication Type:Journal Article
- Keywords:
Dahuang Sodium Bicarbonate Tablets;
quality standard;
TLC;
UPLC fingerprints;
content determination
- From:
Chinese Traditional Patent Medicine
2025;47(7):2137-2144
- CountryChina
- Language:Chinese
-
Abstract:
AIM To improve the quality standard for Dahuang Sodium Bicarbonate Tablets.METHODS TLC was adopted in the qualitative identification of rhein,emodin,chrysophanol,aloe-emodin,physcion and rhapontin,after which UPLC fingerprints were established,content determination of aloe emodin-8-O-β-D-glucoside,rhein-8-O-β-D-glucoside,emodin-8-O-β-D-glucoside,chrysophanol-8-O-β-D-glucoside,physcion-8-O-β-D-glucoside,aloe-emodin,rhein,emodin,chrysophanol,physcion were performed.RESULTS The clear TLC plots demonstrated good specificity.There were 20 common peaks in the fingerprints for 8 batches of samples with the similarities of more than 0.535.Ten constituents showed good linear relationships within their own ranges(r≥0.997 0),whose average recoveries were 98.7％-104.1％with the RSDs of 0.59％-2.13％,whose content ranges were 0.274 1-2.005 9,0.547 8-5.192 2,1.209 2-3.936 3,1.039 3-3.330 2,0.307 0-1.248 1,0.118 2-0.674 7,0.115 1-0.970 3,0.224 5-1.789 3,0.881 4-4.882 6,0.801 4-5.099 1 mg/g,respectively.CONCLUSION This simple and stable method can effectively control the quality of Rhei Radix et Rhizoma in Dahuang Sodium Bicarbonate Tablets.
