Clinical effects of Mahuang Fuzi Xixin Decoction combined with non-immunosuppressive treatment on patients with focal segmental glomerulosclerosis due to Spleen-Kidney Yang Deficiency
10.3969/j.issn.1001-1528.2025.07.016
- VernacularTitle:麻黄附子细辛汤联合非免疫抑制治疗对脾肾阳虚型局灶节段性肾小球硬化患者的临床疗效
- Author:
Tian-wen YAO
1
;
Shi-sheng HAN
1
;
Zhe-ling SU
1
;
Yan-qiu XU
1
;
Yi WANG
1
Author Information
1. 上海中医药大学附属岳阳中西医结合医院,上海 200437
- Publication Type:Journal Article
- Keywords:
Mahuang Fuzi Xixin Decoction;
non-immunosuppressive treatment;
focal segmental glomerulosclerosis;
Spleen-Kidney Yang Deficiency;
TCM syndromes;
podocyte injury
- From:
Chinese Traditional Patent Medicine
2025;47(7):2238-2242
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the clinical effects of Mahuang Fuzi Xixin Decoction combined with non-immunosuppressive treatment on patients with focal segmental glomerulosclerosis due to Spleen-Kidney Yang Deficiency.METHODS Sixty patients were randomly assigned into control group(30 cases)for 24-week intervention of non-immunosuppressive treatment,and observation group(30 cases)for 24-week intervention of both Mahuang Fuzi Xixin Decoction and non-immunosuppressive treatment.The changes in clinical effects,TCM syndrome effects,TCM syndrome score,24 h UTP,ALB,eGFR,Nephrin,Podocin and safety indices were detected.RESULTS The observation group demonstrated higher total effective rate and TCM syndrome effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased TCM syndrome score,24 h UTP,Nephrin,Podocin(P＜0.05),and increased ALB(P＜0.05),especially for the observation group(P＜0.05).No obvious adverse reactions occured in the two groups.CONCLUSION For the patients with focal segmental glomerulosclerosis due to Spleen-Kidney Yang Deficiency,Mahuang Fuzi Xixin Decoction combined with non-immunosuppressive treatment can improve TCM syndromes,whose action mechanism may be contribute to the alleviation of podocyte injury.
