Research Progress in TCM Targeted Regulating Macrophages for the Treatment of Ulcerative Colitis
10.19879/j.cnki.1005-5304.202408326
- VernacularTitle:中医药靶向调控巨噬细胞治疗溃疡性结肠炎研究进展
- Author:
Jiamin ZHU
1
;
Xiaoyan HUANG
;
Shasha CHEN
;
Shi CHENG
;
Jinqiu HUANG
;
Huazhu QIN
Author Information
1. 广西中医药大学研究生院,广西 南宁 530001
- Publication Type:Journal Article
- Keywords:
ulcerative colitis;
macrophage;
traditional Chinese medicine;
review
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(8):186-192
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis(UC)is an inflammatory disease characterized by a continuous diffuse lesion in the colorectal mucosa.Macrophages,as key players in the inflammatory microenvironment,are significantly correlated with the development of UC.Based on the TCM pathogenesis of UC,this article reviewed the current research status of targeted regulation of macrophages in the treatment of UC using TCM,summarized the biological processes related to macrophages and their role in the progression of UC,and concluded the molecular mechanism of TCM treatment of UC targeting macrophages.It found that the active components of Chinese materia medica,TCM compounds,and TCM non-pharmacological therapies mainly regulate macrophage activity by regulating macrophage polarization,autophagy,pyroptosis,metabolic reprogramming,oxidative stress,and other processes,thereby delaying the progression of UC.This article aimed to provide references for in-depth exploration of the pathogenesis of UC and the TCM prevention and treatment of UC.
