Prediction of matrix γ-carboxyglutamic acid protein for cardiovascular events in patients with acute myocardial infarction after PCI
10.3969/j.issn.1009-0126.2025.08.003
- VernacularTitle:急性心肌梗死患者基质γ-羧基谷氨酸蛋白对经皮冠状动脉介入治疗术后心血管事件的预测
- Author:
Xiaoju YAN
1
;
Meng LI
1
;
Shuai LIU
1
;
Yong LI
1
;
Huijing ZHANG
1
Author Information
1. 053000 衡水市人民医院心血管内科
- Publication Type:Journal Article
- Keywords:
myocardial infarction;
1-carboxyglutamic acid;
percutaneous coronary intervention
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(8):986-990
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of matrix γ-carboxyglutamic acid protein(matrix GLA protein)expression in patients with acute myocardial infarction(AMI)for major adverse cardiovascular events(MACE)after percutaneous coronary intervention(PCI).Methods A total of 157 AMI patients undergoing PCI in our department from November 2021 to Septem-ber 2023 were recruited,and divided into a MACE group(43 cases)and a non-MACE group(114 cases)based on the occurrence of MACE over a 12-month follow-up period post-surgery.Multiva-riate logistic regression analysis was used to screen the predictors of MACE and to verify their predictive value.Results The MACE group had significantly older age,larger proportion of diabe-tes,and higher low-density lipoprotein cholesterol(LDL-C)level,but lower matrix GLA protein level than the non-MACE group(P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that age(OR=1.168,95％CI:1.004-1.358,P=0.044),diabetes(OR=3.085,95％CI:1.024-9.301,P=0.045)and LDL-C(OR=2.473,95％CI:1.185-5.163,P=0.016)were risk factors,and matrix GLA protein(OR=0.527,95％CI:0.426-0.653,P=0.001)was a protective factor for MACE in AMI patients after PCI.ROC curve analysis indicated that matrix GLA pro-tein had the highest predictive value of MACE in AMI patients after PCI,with an AUC value of 0.838(95％CI:0.770-0.892).After adjusting for age,diabetes,and LDL C,the restricted cubic spline revealed that matrix GLA protein level was in a nonlinear negative correlation with MACE risk(x2=30.260,P＜0.05).Conclusion Matrix GLA protein can predict the occurrence of MACE in AMI patients after PCI.
