Clinical effects of Supplemented Baihe Gujin Decoction on elderly patients with postoperative pulmonary infection following non-small cell lung cancer surgery
10.3969/j.issn.1001-1528.2025.07.015
- VernacularTitle:加味百合固金汤对非小细胞肺癌术后肺部感染老年患者的临床疗效
- Author:
Ning SHEN
1
;
Meng-ru QIU
;
Qing-yin LIU
;
Xue LIU
;
Wei ZHANG
Author Information
1. 山东中医药大学附属医院,山东济南 250000;山东中医药大学第一临床学院,山东济南 250000
- Publication Type:Journal Article
- Keywords:
Supplemented Baihe Gujin Decoction;
conventional treatment;
non-small cell lung cancer;
lung infection;
immune functions;
inflammatory responses
- From:
Chinese Traditional Patent Medicine
2025;47(7):2234-2238
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the clinical effects of Supplemented Baihe Gujin Decoction on elderly patients with postoperative pulmonary infection following non-small cell lung cancer surgery.METHODS Ninety-two patients were randomly assigned into control group(46 cases)for 1-week intervention of conventional treatment,and observation group(46 cases)for 1-week intervention of both Supplemented Baihe Gujin Decoction and conventional treatment.The changes in clinical effects,TCM syndrome scores,immune function indices(CD3+,CD4+,CD8+,CD4+/CD8+),inflammatory indices(CRP,PCT,TNF-α),serum indices(sTREM-1,CD40L,NLR)and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,CD8+,inflammatory indices,serum indices(P＜0.05),and increased CD3+,CD4+,CD4+/CD8+(P＜0.05),especially for the observation group(except for CD4+,CD8+)(P＜0.05).CONCLUSION For the elderly patients with postoperative pulmonary infection following non-small cell lung cancer surgery,Supplemented Baihe Gujin Decoction can safely and effectively relieve clinical symptoms,enhance immune functions,reduce serum sTREM-1,CD40L levels and NLR,and control inflammatory responses.
