Study on the correlation between retinal vascular diameter and LDL-C in patients with type 2 diabetes mellitus
10.3969/j.issn.1673-9701.2025.19.009
- VernacularTitle:2型糖尿病患者视网膜血管直径与LDL-C的相关性研究
- Author:
Lili LIN
1
;
Jingfen XU
1
;
Rongzhou YE
1
;
Xiuyan LI
1
;
Qian LI
1
Author Information
1. 福建医科大学附属泉州第一医院全科医学科,福建泉州 362000
- Publication Type:Journal Article
- Keywords:
Diabetic retinopathy;
Low density lipoprotein-cholesterol;
Retinal vascular diameter
- From:
China Modern Doctor
2025;63(19):42-45,50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of low density lipoprotein-cholesterol(LDL-C)on the diameters of retinal arteries and veins in patients with type 2 diabetes mellitus(T2DM).Methods A total of 102 patients with T2DM who treated in Quanzhou First Hospital Affiliated to Fujian Medical University from January to September 2024 were selected and divided into Group A(LDL-C＜2.6mmol/L,35 cases),Group B(2.6mmol/L≤LDL-C＜3.4mmol/L,33 cases)and Group C(LDL-C≥3.4mmol/L,34 cases)according to the LDL-C level.The clinical data and color fundus photos of the patients were collected.The superior temporal retinal arteriolar equivalent(RAE)and superior temporal retinal venular equivalent(RVE)in the left eye of patients were measured,and the ratio of arteriovenous diameters(AVR)was calculated.The correlation between LDL-C levels and retinal vascular diameters was analyzed.Results There were statistically significant differences in levels of total cholesterol and triglycerides,as well as the proportions of patients with coronary heart disease and diabetic retinopathy(DR)among the three groups(P＜0.05).With the progression of DR,the level of LDL-C gradually increases(P＜0.05).There were statistically significant differences in RAE and AVR among patients with different DR stages(P＜0.05).There were statistically significant differences in RAE and AVR among three groups of patients(P＜0.05).Correlation analysis showed that RAE and AVR were negatively correlated with LDL-C(P＜0.05).Conclusion With the increase of LDL-C level,the degree of DR aggravates,and RAE and AVR decrease accordingly.However,there is no significant correlation between LDL-C and RVE.
