The diagnostic value of serum miR-181b and lncRNA MIAT in hypertensive nephropathy
10.3969/j.issn.1673-9701.2025.19.007
- VernacularTitle:miR-181b和lncRNA MIAT对高血压肾病的诊断价值
- Author:
Yun CHEN
1
;
Chao LI
Author Information
1. 金华市人民医院肾内科,浙江金华 321002
- Publication Type:Journal Article
- Keywords:
Essential hypertension;
Hypertensive nephropathy;
MiR-181b;
LncRNA MIAT
- From:
China Modern Doctor
2025;63(19):32-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the diagnostic value of serum miR-181b and long noncoding RNA(lncRNA)myocardial infarction association transcript(MIAT)for hypertensive nephropathy.Methods A total of 120 patients with essential hypertension admitted to Jinhua People's Hospital from October 2022 to October 2024 were selected as research subjects.According to urinealbumin-to-creatinine ratio,they were divided into hypertensive nephropathy group(68 cases)and simple hypertension group(52 cases),and another 60 healthy individuals undergoing physical examinations during the same period were selected as control group.The serum miR-181b,lncRNA MIAT,hypersensitive C-reaction protein(hs-CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in each group were compared.Results There were statistically significant differences in hs-CRP,TNF-α,IL-6,miR-181b and lncRNA MIAT among three groups(P＜0.05).Among them,the levels of hs-CRP,TNF-α,IL-6 and lncRNA MIAT in hypertensive nephropathy group＞simple hypertension group＞control group,and miR-181b level was in hypertensive nephropathy group＜simple hypertension group＜control group.The results of Pearson correlation analysis showed that expression of serum miR-181b in patients with hypertensive nephropathy was negatively correlated with the levels of lncRNA MIAT,hs-CRP,TNF-α,and IL-6(P＜0.05),while expression of lncRNA MIAT was positively correlated with the levels of hs-CRP,TNF-α,and IL-6(P＜0.05).The sensitivity of miR-181b and lncRNA MIAT in the diagnosis of hypertensive nephropathy evaluated by receiver operating characteristic curve was 97.1％and 73.5％respectively,the specificity was 68.7％and 92.1％respectively,and area under the curve were 0.819 and 0.951 respectively.Conclusion miR-181b and lncRNA MIAT are abnormally expressed in the serum of patients with hypertensive nephropathy and are expected to become potential markers for early diagnosis of hypertensive nephropathy.
