Causal relationship between 25-hydroxyvitamin D and ankylosing spondylitis:A two-way Mendelian randomization study
10.3969/j.issn.1673-9701.2025.19.001
- VernacularTitle:25-羟维生素D与强直性脊柱炎的因果关系:双向孟德尔随机化研究
- Author:
Lang XIONG
1
;
Zong JIANG
;
Weiya LAN
;
Fang TANG
;
Wukai MA
;
Xueyong CHEN
;
Shanshan CAI
;
Haixia TU
;
Yuqing DAI
;
Shanyan CAI
Author Information
1. 贵州中医药大学第二临床医学院,贵州贵阳 550002
- Publication Type:Journal Article
- Keywords:
25-hydroxyvitamin D;
Ankylosing spondylitis;
Mendelian randomization;
Causality
- From:
China Modern Doctor
2025;63(19):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore causal relationship between 25-hydroxyvitamin D[25(OH)D]and ankylosing spondylitis(AS).Methods Genetic data of 25(OH)D and AS were extracted from the genome-wide association study.The causal effect of 25(OH)D on AS was estimated by MR-Egger regression method,weighted median,inverse variance weighted(IVW),simple mode and weighted mode,and sensitivity analysis was conducted for verification.Results The IVW results indicated that there was a causal relationship between 25(OH)D concentration and AS(OR=0.805,95％CI:0.686-0.944,P=0.008),and the maximum likelihood ratio(OR=0.799,95％CI:0.678-0.940,P=0.007)showed consistent results.The IVW results of the reverse Mendelian randomization study showed that there was no causal relationship between the two(OR=1.019,95％CI:0.995-1.043,P=0.110).In addition,MR-Egger intercept,Cochran Q test,"leave-one-out"and MR-PRESSO analysis showed no horizontal pleipotency or heterogeneity.Conclusion There may be a genetic causal relationship between the concentration of 25(OH)D and the onset of AS.AS cannot cause changes in the concentration of 25(OH)D in the body.
