LASSO regression and Mendelian randomization were used to explore the relationship between asthma and hypertension
10.3969/j.issn.1673-9701.2025.19.014
- VernacularTitle:LASSO回归和孟德尔随机化探讨哮喘与高血压的关系
- Author:
Zhihao ZOU
1
;
Yunpeng WANG
1
;
Jijing ZHAO
1
Author Information
1. 建德市第一人民医院呼吸内科,浙江建德 311600
- Publication Type:Journal Article
- Keywords:
LASSO regression;
Mendelian randomization;
Asthma;
Hypertension
- From:
China Modern Doctor
2025;63(19):65-69
- CountryChina
- Language:Chinese
-
Abstract:
Objective The relationship between asthma and hypertension was explored by using the least absolute shrinkage and selection operator(LASSO)regression and Mendelian randomization(MR).Methods Data from the National Health and Nutrition Examination Survey(NHANES)of the United States from 2001 to 2018 were selected.LASSO regression was used to screen variables,and a nomogram prediction model for hypertension risk was established.The model was verified to evaluate its predictive ability and stability for the risk of hypertension.Finally,two-sample MR analysis was used to verify the causal relationship.Results The study ultimately included 26 456 cases,including 8833 hypertensive patients.LASSO regression screened out 9 variables,including age,educational level,race,marital status,smoking history,asthma,diabetes,cancer and body mass index,and a nomogram model was constructed based on these variables.The calibration curve indicated that there was a good fit between two groups.After adjusting for the measured confounding factors,the inverse variance weighted analysis showed that asthma was associated with an increased risk of hypertension(OR=2.67,95％CI:1.31-5.43,P＜0.01).Conclusion There is a causal relationship between asthma and hypertension,and controlling asthma conditions may help reduce the risk of developing hypertension.
