Establishment of an animal model of osteosarcoma and tissue engineering application in osteosarcoma modeling
10.3781/j.issn.1000-7431.2025.2404-0185
- VernacularTitle:骨肉瘤动物模型的建立及组织工程学在骨肉瘤模型中的应用进展
- Author:
Peixin WANG
1
;
Jun ZHAO
;
Shihong XU
;
Chaoyang JIANG
;
Xiaoqiang WANG
;
Hongjuan YANG
Author Information
1. 甘肃中医药大学中医临床学院,甘肃 兰州 730000
- Publication Type:Journal Article
- Keywords:
Osteosarcoma;
Animal model;
Metastatic model;
Tissue engineering model
- From:
Tumor
2025;45(1):85-92
- CountryChina
- Language:Chinese
-
Abstract:
Osteosarcoma is a primary bone tumor originating from mesenchymal tissues,highly aggressive and metastatic,and is one of the causes of orthopedic disorders in children and adolescents.The establishment of an osteosarcoma model is useful for studying the changes in the physiology and pathology of the organism after the occurrence of osteosarcoma.The establishment methods of osteosarcoma models not only differ in terms of difficulty,tumorigenicity,tumor-formation time,tumor survival time,tumor metastasis,and safety,but also in terms of simulating human osteosarcoma biological characteristics and histological features.In addition,the wide application of tissue engineering in tumor modeling is conducive to better study the role of the osteosarcoma microenvironment in osteosarcoma genesis and development.In this paper,we summarize the roles of different osteosarcoma animal models and their tissue engineering models in different experiments,in order to provide help for the study of osteosarcoma pathogenesis and drug intervention mechanism.
