Overview of the application of prescription sequence symmetry analysis in pharmacovigilance

VernacularTitle:处方序列对称分析在药物警戒中的应用概述
Author: Wei DOU ¹ ; Xin LIU ¹ ; Wei ZUO ¹ ; Jiaxin YU ¹ ; Jiayu WU ¹ ; Bo ZHANG ¹
Author Information

1. 中国医学科学院北京协和医学院北京协和医院药剂科，疑难重症及罕见病国家重点实验室，北京　100730
Publication Type:Journal Article
Keywords: Prescription drug monitoring programs; Pharmacovigilance; Data mining; Prescription sequence analysis; Prescription sequence symmetry analysis; Medication
From: Adverse Drug Reactions Journal 2025;27(6):362-368
CountryChina
Language:Chinese
Abstract: Prescription sequence symmetry analysis (PSSA) is one of the important methods for post-marketing pharmacovigilance based on the real-world medical prescription databases. It can be used to detect prescription cascades and mine adverse drug reaction (ADR) signals, which has been verified by many studies. PSSA shows high specificity and medium sensitivity in identifying ADR. It can quantify the correlation or risks of ADR. It is easy to use and simple in algorithm, and it has good robustness to some non time-dependent confounding factors. However, the results may be affected by some human confounding factors and data quality. This paper reviews the principle, calculation method, application scope, and precaution of PSSA by reviewing related literature on PSSA domestically and abroad, in order to provide reference for pharmacovigilance in China.