Risk and prevention of perioperative pulmonary aspiration caused by delayed gastric emptying associated with semaglutide
10.3760/cma.j.cn114015-20240729-00657
- VernacularTitle:司美格鲁肽相关胃排空延迟致围手术期肺误吸的风险及预防
- Author:
Wenxin XUE
1
;
Tianlong HAO
;
Wei CHEN
;
Jingxin WANG
;
Keming CAO
Author Information
1. 应急总医院药学部，北京 100028
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, type 2;
Obesity;
Semaglutide;
Gastric emptying;
Perioperative period;
Anesthesia, general;
Respiratory aspiration of gastric contents
- From:
Adverse Drug Reactions Journal
2025;27(5):308-312
- CountryChina
- Language:Chinese
-
Abstract:
Semaglutide is a long-acting glucagon-like peptide-1 receptor agonist (GLP-1RA), which is commonly used in the treatment of type 2 diabetes mellitus and weight loss. Its weight loss effect was exerted mainly by suppressing appetite, delaying gastric emptying, promoting energy metabolism, and accelerating lipolysis. However, delayed gastric emptying can lead to residual gastric content, increasing the risk of pulmonary aspiration during anesthesia. This article reviews the effects and mechanisms of semaglutide on gastric emptying, and proposes preventive measures for perioperative pulmonary aspiration in patients treated with semaglutide by reviewing case reports and clinical studies on semaglutide-related delayed gastric emptying. This provides a reference for the safety of semaglutide treatment during the perio- perative period.
