Acute lung injury due to recombinant human granulocyte colony-stimulating factor in a healthy donor
10.3760/cma.j.cn114015-20230923-00707
- VernacularTitle:重组人粒细胞集落刺激因子致健康供者急性肺损伤
- Author:
Yuhui PANG
1
;
Shaofei ZHANG
;
Rongxiao WANG
;
Jianzhu CAO
;
Jinxia LIU
;
Yaochen ZHANG
Author Information
1. 石家庄平安医院血液科，石家庄 050021
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation;
Acute lung injury;
Recombinant human granulocyte colony-stimulating factor;
Healthy donor
- From:
Adverse Drug Reactions Journal
2024;26(9):568-570
- CountryChina
- Language:Chinese
-
Abstract:
A 36-year-old healthy male served as an allogeneic hematopoietic stem cell donor was given recombinant human granulocyte colony-stimulating factor injection (rhG-CSF) 300 μg by subcutaneous injection once daily for 5 consecutive days. On day 4 of stem cell mobilization, peripheral stem cell collection was performed and rhG-CSF 250 μg was given in addition. The donor experienced dry cough, dyspnea, and difficulty breathing on the next day. Chest CT scan showed diffuse patchy and nodular shadows in both lungs, and relevant tests excluded bacterial/viral infection of the lungs and heart failure. It was considered to be acute lung injury caused by rhG-CSF. After giving glucocorticoids and symptomatic treatments, the symptoms gradually subsided, and the peripheral blood stem cell collection was successful. In the continuing treatment of glucocorticoids, the symptoms of the donor were further improved, and chest CT scan showed marked improvement. At a 3 years of follow-up, the donor' work and life were normal, and no lung discomfort symptoms recurred.
