Observation on difference of iron deposition in deep brain nuclei of systemic lupus erythematosus patients with different disease activity levels using quantitative susceptibility mapping
10.13929/j.issn.1003-3289.2025.04.017
- VernacularTitle:基于定量磁化率成像观察不同活动度系统性红斑狼疮患者脑深部核团铁沉积差异
- Author:
Zihao LEI
1
;
Chao TAO
1
;
Liang XU
1
;
Haitao DIAO
1
;
Jian ZHAI
1
;
Yongmei YU
1
Author Information
1. 皖南医学院第一附属医院放射科,安徽 芜湖 241001
- Publication Type:Journal Article
- Keywords:
lupus erythematosus,systemic;
putamen;
iron;
magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2025;41(4):587-591
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the difference of iron deposition in brain deep nuclei of systemic lupus erythematosus(SLE)patients with different disease activity levels using quantitative susceptibility mapping(QSM).Methods Fifty-four SLE patients were retrospectively enrolled and divided into moderate to severe activity group(score＞9,n=25)and mild activity group(score≤9,n=29)according to SLE disease activity index(SLEDAI)score.Patients' general clinical data,as well as the mean QSM of bilateral head of caudate nuclei,putamina,globi pallidi,red nuclei,substantiae nigrae,dentate nuclei and thalami were compared between groups.Pearson or Spearman coefficients were performed to analyze correlations of the mean QSM of nuclei being significant different between groups and conventional clinical indicators.Then receiver operating characteristic(ROC)curve was drawn,and the area under the curve(AUC)was calculated to evaluate the efficacy of the mean QSM for distinguishing moderate to severe and mild activity SLE.Results Compared with mild activity group,moderate to severe activity group had higher serum ferritin,erythrocyte sedimentation rate(ESR),C reactive protein(CRP),anti-double stranded DNA(anti-dsDNA)antibody levels,also higher proportion of positive anti-ribosomal P protein(anti-P)antibodies,but lower complement C3 and C4 levels(all P＜0.05).The mean QSM of bilateral putamina and thalami were significantly higher in moderate to severe activity group than in mild activity group(both P＜0.05).The mean QSM of bilateral putamina was positively correlated with SLEDAI scores,ferritin levels and positivity of anti-P antibodies in SLE patients(with r or rs of 0.447,0.526 and 0.473,respectively,and all P＜0.05).The AUC for distinguishing moderate to severe SLE and mild activity SLE based on the mean bilateral putamina QSM was 0.810.Conclusion There were significant differences of iron deposition in deep brain nuclei of SLE patients with moderate to severe and mild activity.The mean QSM of bilateral putamina could be used to distinguish SLE with moderate to severe activity and mild activity.
