Safety of local anesthetics and the research progress of their new dosage forms
10.3760/cma.j.cn114015-20230621-00455
- VernacularTitle:局部麻醉药的安全性及其新剂型研究进展
- Author:
Yuanchao ZHU
1
;
Yatong ZHANG
1
;
Liang LIANG
1
Author Information
1. 北京医院药学部/国家老年医学中心/中国医学科学院老年医学研究院/北京市药物临床风险与个体化应用评价重点实验室（北京医院），北京 100730
- Publication Type:Journal Article
- Keywords:
Anesthetics, local;
Administration, cutaneous;
Dosage forms;
Safety;
Drug- related side effects and adverse reactions
- From:
Adverse Drug Reactions Journal
2024;26(2):111-117
- CountryChina
- Language:Chinese
-
Abstract:
Local anesthetics are a class of medications that can reversibly block the occurrence and transmission of sensory nerve impulses in the local administration area, which are widely used in clinic for skin and mucous membrane anesthesia, peripheral nerve block anesthesia, spinal nerve anesthesia, and the treatment of chronic pain. The adverse reactions of local anesthetics mainly include allergic reactions, cardiotoxicity, and neurotoxicity. The new dosage forms of local anesthetics include cutaneous administration and sustained-release formulations. The advantage of cutaneous administration is to achieve surface local anesthesia, avoid liver first pass effect, reduce local damage and stimulation caused by injection anesthesia, and improve patient tolerance. The sustained-release dosage form can help maintain a longer lasting anesthetic effect, avoid excessive blood drug concentration caused by rapid absorption of local anesthetic drugs, and thus reduce adverse drug reactions.
