Influencing Factors of Postoperative Live Birth in Patients With Tubal Ectopic Pregnancy Who Had Received in vitro Fertilization/Intracytoplasmic Sperm Injection Embryo Transfer
10.3969/j.issn.1009-6604.2025.05.001
- VernacularTitle:体外受精或卵胞质内单精子注射-胚胎移植后输卵管妊娠患者术后再次活产的影响因素分析
- Author:
Yimeng GE
1
;
Shuo YANG
1
;
Rong LI
1
Author Information
1. 北京大学第三医院生殖医学中心 国家妇产疾病临床医学研究中心 辅助生殖教育部重点实验室 北京市生殖内分泌与辅助生殖技术重点实验室,北京 100191
- Publication Type:Journal Article
- Keywords:
Ectopic pregnancy;
Inflammatory pelvic disease;
Pregnancy outcome;
Live birth
- From:
Chinese Journal of Minimally Invasive Surgery
2025;25(5):257-263
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the influencing factors of postoperative live birth in patients with tubal ectopic pregnancy who had received fresh double cleavage-stage embryo transfer through in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI).Methods A retrospective cohort study was performed by analyzing clinical data of patients receiving laparoscopic salpingectomy for clinical diagnosed tubal ectopic pregnancy who had undergone double fresh cleavage-stage embryo transfer in our department from January 2016 to June 2018.A follow-up study was performed in terms of pregnancy outcomes in patients who were willing to conceive or attempt pregnancy for 6 years after the operation.The patients were categorized into two groups according to postoperative pregnancy outcomes.A logistic regression analysis was performed to analyze the influencing factors of postoperative live births.Results A total of 188 patients were included,110 of which had live birth within 6 years after surgery,with a live birth rate of 58.5％(110/188).A multivariate logistic regression analysis was conducted on variables with P＜0.2 in the univariate analysis(age,duration of infertility,ovarian reserve dysfunction,number of egg retrieval after laparoscopic resection,endometrial thickness,pelvic adhesions,and fimbrial morphology of the fallopian tube)and the baseline antral follicle count in the last transplantation cycle of the live birth cycle(P=0.205),which would affect the outcome of subsequent pregnancy.The analysis showed that pelvic single site and multiple site dense adhesions were independent prognostic factors affecting the live birth again(OR=0.185,95％ CI:0.046-0.736,P=0.017;OR=0.124,95％ CI:0.024-0.640,P=0.013).Conclusions Intraoperative pelvic adhesion negatively affects the pregnancy outcomes of patients diagnosed with tubal ectopic pregnancy who have received fresh double cleavage-stage embryo transfer,and is an independent prognosis factor for postoperative live birth within 6 years.Improving pelvic adhesion and preventing pelvic inflammatory disease are beneficial for refining fertility outcome after surgery.
