Pay attention to the prevention and supervision of important organ damage related to acetaminophen
10.3760/cma.j.cn114015-20230807-00587
- VernacularTitle:重视对乙酰氨基酚相关重要器官损伤的防范和监管
- Author:
Tingting FAN
1
;
Juanli ZHANG
1
;
Likun DING
1
;
Di ZHANG
1
;
Danjun REN
1
;
Meiyou LIU
1
;
Jingwen WANG
1
;
Aidong WEN
1
Author Information
1. 空军军医大学第一附属医院药剂科，西安 710032
- Publication Type:Journal Article
- Keywords:
Acetaminophen;
Drug-related side effects and adverse reactions;
Chemical and drug induced liver injury;
Cardiotoxicity;
Acute kidney injury;
Safety managem
- From:
Adverse Drug Reactions Journal
2024;26(2):65-69
- CountryChina
- Language:Chinese
-
Abstract:
Acetaminophen is currently the most widely used antipyretic analgesics in clinical practice. The conventional dose of acetaminophen is safe and reliable, and long-term use in large quantities can cause damage to important organs. In recent years, some new safety issues of acetaminophen have been found, such as its possibility to increase blood pressure in patients with hypertension, its association with increased risk of cardiovascular disease and all-cause mortality with sodium-containing acetaminophen, the discovery of multiple biomarkers for predicting and diagnosing acetaminophen-related liver injury and its prognosis, and its possibility to increase the risk of kidney injury. The safety prevention strategies for important organ injuries related to acetaminophen include strict restrictions on medication dosage and duration, and attention to medication safety for special populations. For patients who have experienced significant organ damages, their causal relationship should be evaluated, acetaminophen should be stopped, and specific treatment, and symptomatic and supportive treatments should be provided.
