Research progress on neurotoxicity related to chimeric antigen receptor T cell immunotherapy
10.3760/cma.j.cn114015-20210726-00826
- VernacularTitle:嵌合抗原受体T细胞免疫疗法相关神经毒性研究进展
- Author:
Wei CHEN
1
;
Shuling HOU
1
;
Pan CHEN
1
;
Xueping DANG
1
Author Information
1. 山西医科大学第三医院（山西医学科学院/山西白求恩医院/同济山西医院）肿瘤内科，太原 030032
- Publication Type:Journal Article
- Keywords:
Immunotherapy;
Chimeric antigen receptor;
Neurotoxicity syndromes
- From:
Adverse Drug Reactions Journal
2022;24(2):88-91
- CountryChina
- Language:Chinese
-
Abstract:
Immune effector cell-associated neurotoxicity syndrome (ICANS) is a common adverse reaction of chimeric antigen receptor T-cell (CAR-T) immunotherapy. Its mechanism is mainly related to the destruction of brain mural cells, increase of cytokine level, the inflammation mediated by natural killer cells, and the activation of endothelial cells. The main clinical manifestations of ICANS are aphasia, tremor, dysgraphia, drowsiness, and epilepsy. In severe cases, asphyxia, coma, or brain edema may occur, and sometimes it is even life-threatening. The factors affecting ICANS include age, peak value of CAR-T amplification, product type, and disease type, etc. American Society for Blood and Marrow Transplantation recommends symptomatic and supportive treatments for mild ICANS and hormonal shock therapy for severe cases.
